Organ Preservation Clinical Trial
Official title:
Ex Vivo Lung Perfusion : Evaluating the Effect of Cellular Perfusate on Mechanical Properties and Gas Exchange Function of the Donor Lungs : A Randomised Cross Over Study
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it . Blood will be added to the fluid depending on the group to which the lungs are allocated and its effects on lung function will be seen
The lungs of a brain dead multi organ donor will be retrieved according to standard protocol. Once a decision is made not to transplant the lungs either because of not satisfying ideal criteria or in the absence of a potential recipient they will be included in the study.They will be ventilated optimally and connected to a cardiopulmonary bypass machine for circulating preservative solution through it . Red blood cells will be added to the solution either initially or later depending on the group to which it is allocated .Monitoring of mechanical and gas exchange function and pathological examination of the lungs will be performed at various time points to observe the effect of red blood cells. The lungs will be properly discarded at the end of the procedure and will not be used for transplantation. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01330056 -
Functional Organ Preservation Surgery
|
N/A | |
| Suspended |
NCT04558684 -
Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05898776 -
10°C vs 4°C Lung Preservation RCT
|
N/A | |
| Completed |
NCT00879268 -
Vasosol Organ Perfusion Solution and Medtronic Portable Bypass System
|
Phase 1 | |
| Completed |
NCT04569682 -
Outcomes of Transrenal Artery Perfusion Versus Transrenal Vein Perfusion Using LifePort for Deceased Donor Kidney Transplantation
|
N/A | |
| Completed |
NCT03846726 -
Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response
|
||
| Completed |
NCT05520320 -
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
|
||
| Recruiting |
NCT06263023 -
A Central Preservation and Assessment Service to Optimize Donor Kidney Allocation
|
||
| Recruiting |
NCT05772923 -
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
|
N/A |