Oral Submucous Fibrosis Clinical Trial
Official title:
Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis - a Clinico-pathological Study
The etiology of OSMF is considered to be multifactorial. However, Role of autoimmunity had
been suggested as one of the factors but remains unproven.
The present study is undertaken to evaluate the presence of auto antibodies in OSMF patients
to pave a way for new arena of treatment with the etiology of this persistent condition
Oral submucous fibrosis (OSMF) is a potentially malignant disorder affecting any part of the
oral cavity, sometimes pharynx associated with juxta epithelial fibrosis causing progressive
trismus leading to dysphagia. It is mainly seen in the Asian countries with more prevalence
in India.
Etiology of OSMF is considered to be multifactorial. However, it is strongly associated with
the use of arecanut in various forms and also in combination with other compounding factors.
Autoimmunity had been suggested as one of the factors yet unproven.
Few studies reveal that there is high incidence of Autoantibodies including antinuclear
(ANA), Anti smooth muscle (SMA), Anti thyroid microsomal (TMA), and anti reticulin antibodies
in OSMF patients. These findings have not been consistent in further studies which needs
further more research in this.
A study concentrated on quantitation of circulating immune complexes (CIC) levels which was
established in patients with oral cancer and oral precancerous lesions. The levels were
compared with that in normal controls and chronic chewers of betel quid with no signs of any
disease. Both patients with oral cancer and oral precancerous lesions had elevated CIC when
compared to both the control groups. The most interesting observations were (a) the CIC
levels in the chewing controls were significantly raised when compared to normal controls;
and (b) the CIC levels in the patients with premalignant lesions were elevated almost to the
same levels as in the oral cancer patients.
HLA-typing was carried on areca nut chewers. however, it was unable to demonstrate a specific
pattern of HLA-antigen frequencies in chewers with or without the disease. It is not
necessarily a HLA-associated susceptibility in Oral Submucous Fibrosis.
Due to less number of articles published on autoantibodies, this study is done to evaluate
the presence of such auto antibodies in OSMF patients thereby paving way for new arena of
treatment on par with the etiology of this persistent condition.
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