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Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva

Oral Soft Tissue Conditions Clinical Trial

Official title:
Investigation of the Endothel Dependent and Independent Vasodilatation in Human Gingiva: Comparison of the Effect of NO and ACH

Clinical Trial Summary

The aim of this study is to compare the endothelim-dependent and non-dependent vasodilatation between genders in the human gingiva.

Clinical Trial Description

Gender differences were observed in studies according to gingival microcirculation between physiological circumstances and during wound healing as well. For blood flow measurement Laser Spackle Contrast Imaging is a reliable tool. It has good reproducibility, it doesn't get in touch with the measured surface, it's easy to use and it can measure on a bigger surface in same time. Two wells were fabricated on the labial surface of the right lateral incisor (test tooth) and on the labial surface of the left central incisor (control tooth). These wells are opened towards the high-prermeability gingival sulcus, so the dropped solutions nitroglycerine vs physiological saline or nitroglycerine vs physiological saline can esasily penetrate to the gingival tissues. After applying the solutions, the blood flow was monitored fot 15 minutes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04918563
Study type Interventional
Source Semmelweis University
Contact
Status Completed
Phase N/A
Start date September 15, 2020
Completion date May 15, 2021
View Details
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