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NCT05730855 Clinical Trial

Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions

Oral Lichen Planus Clinical Trial

Official title:
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05730855
Other study ID # 1152014
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2022
Est. completion date January 23, 2023

Study information
Verified date September 2023
Source Fayoum University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.

Recruitment information / eligibility
Status Completed
Enrollment 45
Est. completion date January 23, 2023
Est. primary completion date December 24, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - participants will be divided into 3 groups: Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions. Exclusion Criteria: - Subjects taking any drugs inducing any changes that could affect the salivary flow. - Pregnant females. - Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling. - Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Real-time Polymerase Chain Reaction technique
Real-time Polymerase Chain Reaction technique

Locations
Country Name City State
Egypt Fayoum University Fayoum

Sponsors (1)
Lead Sponsor Collaborator
Fayoum University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary salivary expression of lncDQ786243 in OLP, Leukoplakia, control 2 months
Secondary salivary expression of miRNA146a in OLP, Leukoplakia, control 2 months
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