Oral Lichen Planus Clinical Trial
Official title:
11 El-Saraya St. - Manial - Cairo
The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and determine whether the effect, if any, was due to its antioxidant activity.
Status | Not yet recruiting |
Enrollment | 34 |
Est. completion date | November 2021 |
Est. primary completion date | October 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 15 Years to 70 Years |
Eligibility |
Inclusion Criteria: 1. Patients free from any systemic disease according to the detailed questionnaire of the modified Cornell Medical Index 34. 2. Patients not receiving any medication either topical or systemic that could cause lichenoid reaction during the 3 months before the study. 3. Patients diagnosed by a dermatologist and oral medicine specialist as suffering from OLP. 4. Patients clinically and histopathologically diagnosed as suffering from OLP according to World Health Organization's (WHO's) clinic-pathological diagnostic criteria for LP35. 5. Patients who agree for the biopsy in undiagnosed cases. 6. Patients who are willing to participate in this study (will give informed consent) and have the ability to complete the study. - Exclusion criteria: (1) Patients taking systemic drugs such as systemic steroid, other immunosuppressive therapy for at least 8 weeks prior to the study. (2) Patients treated with any oral topical medications for at least four weeks prior to the study. (3) Patients with suspected restoration-related reaction. (4) Pregnant and lactating mothers. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Cairo University |
Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar 27. Review. — View Citation
Ismail SB, Kumar SK, Zain RB. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007 Jun;49(2):89-106. Review. — View Citation
Scrobota I, Mocan T, Catoi C, Bolfa P, Muresan A, Baciut G. Histopathological aspects and local implications of oxidative stress in patients with oral lichen planus. Rom J Morphol Embryol. 2011;52(4):1305-9. — View Citation
Sugerman PB, Savage NW, Zhou X, Walsh LJ, Bigby M. Oral lichen planus. Clin Dermatol. 2000 Sep-Oct;18(5):533-9. Review. — View Citation
Yang LL, Liu XQ, Liu W, Cheng B, Li MT. Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus. Inflamm Res. 2006 Oct;55(10):405-7. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | pain score | visual analogue scale scoring system | 3months | |
Primary | clinical size of lesion | Thongprasom score system | 3months | |
Secondary | Salivary level of Malondialdehyde | detect by ELISA | 3months |
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