Oral Lichen Planus Clinical Trial
Official title:
Molecular Mechanisms of Precancerous and Cancerous Lesions of the Oral Cavity
Verified date | January 2017 |
Source | University of Zagreb |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this study was to examine molecular alterations on the protein level in lesions
of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa. Global
protein profiling methods based on liquid chromatography coupled to mass spectrometry were
used, with a special emphasis on evaluation of deregulated extracellular matrix molecules
expression, as well as on analyses of insulin-like growtg factor 2 (IG2F) and insulin-like
growth factor 2 receptor (IGFR2) expression in healthy mucosa, OLP and OSCC tissues by
comparative semiquantitative immunohistochemistry.
Mass spectrometry based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and
accompanied histologically unaltered tissues, respectively) identified 55 extracellular
matrix proteins. Twenty among identified proteins were common to all groups of samples.
Statistically significant difference between final IGF2 and IGF2R IRS scores in favour to
IGF2R may further corroborate the IG2FR antitumor role in OLP and OSCC where it acts as a
negative regulator of IGF2 activity.
Status | Completed |
Enrollment | 71 |
Est. completion date | December 2014 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 30 Years to 70 Years |
Eligibility |
Inclusion Criteria: - histopathologically confirmed oral lichen planus and oral squamous cell carcinoma - healthy volunteers referred for alveolotomy Exclusion Criteria: - non-consent patients - previously treated OSCC - patients under immunosuppressive therapy |
Country | Name | City | State |
---|---|---|---|
Croatia | School of Dental Medicine, University of Zagreb | Zagreb |
Lead Sponsor | Collaborator |
---|---|
University of Zagreb | University of Rijeka |
Croatia,
Pawar H, Kashyap MK, Sahasrabuddhe NA, Renuse S, Harsha HC, Kumar P, Sharma J, Kandasamy K, Marimuthu A, Nair B, Rajagopalan S, Maharudraiah J, Premalatha CS, Kumar KV, Vijayakumar M, Chaerkady R, Prasad TS, Kumar RV, Kumar RV, Pandey A. Quantitative tiss — View Citation
Schiller HB, Szekeres A, Binder BR, Stockinger H, Leksa V. Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator rec — View Citation
Zavras AI, Pitiphat W, Wu T, Cartsos V, Lam A, Douglass CW, Diehl SR. Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans. Cancer Res. 2003 Jan 15;63(2):296-7. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Global proteomic profiling of oral lichen planus and oral squamous cell carcinoma | 2012-2014 | ||
Secondary | evaluation of the Insulin-like growth factor receptor 2 (IGF2R) and IGF2 role in oral lichen planus | 2011-2014 |
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