Oral Lichen Planus Clinical Trial
Official title:
Molecular Mechanisms of Precancerous and Cancerous Lesions of the Oral Cavity
The aim of this study was to examine molecular alterations on the protein level in lesions
of oral lichen planus (OLP), oral squamous cell carcinoma (OSCC) and healthy mucosa. Global
protein profiling methods based on liquid chromatography coupled to mass spectrometry were
used, with a special emphasis on evaluation of deregulated extracellular matrix molecules
expression, as well as on analyses of insulin-like growtg factor 2 (IG2F) and insulin-like
growth factor 2 receptor (IGFR2) expression in healthy mucosa, OLP and OSCC tissues by
comparative semiquantitative immunohistochemistry.
Mass spectrometry based proteomics profiling of healthy mucosa, OLP and OSCC tissues (and
accompanied histologically unaltered tissues, respectively) identified 55 extracellular
matrix proteins. Twenty among identified proteins were common to all groups of samples.
Statistically significant difference between final IGF2 and IGF2R IRS scores in favour to
IGF2R may further corroborate the IG2FR antitumor role in OLP and OSCC where it acts as a
negative regulator of IGF2 activity.
Although OLP is categorised as a precancerous condition associated with a significantly
increased risk of oral cancer, molecular pathophysiology of OLP and its potential for
malignant transformation in OSCC are poorly understood and remain controversial. Development
of new analytical methods enhances research in the field of malignant disorders.
Identification of novel biomarkers help in the diagnostic process, pre-symptomatic
interventions or prediction of treatment response. Proteomics based on mass spectrometry
enables analysis of novel, putative biomarkers. In this study, proteomics was used to
analyse in more details extracellular matrix (ECM) proteins and proteins related to ECM
signalization which have a well-established role in malignant transformation and invasion of
tumor cells.
IGF2 and IGF2R are known biomarkers in cellular metabolism,but their role in oral
precancerous lesions, namely oral lichen planus (OLP) as well as in oral squamous cell
carcinoma (OSCC) has not been explored so far. The second aim of our study was to analyse
IG2F and IGFR2 expression in oral lichen planus and oral squamous cell carcinoma tissues by
comparative semiquantitative immunohistochemistry
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