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NCT00484250 Clinical Trial

Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

Oral Lichen Planus Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00484250
Other study ID # 240
Secondary ID
Status Completed
Phase Phase 2
First received June 7, 2007
Last updated June 8, 2007
Start date September 2005
Est. completion date May 2006

Study information
Verified date June 2007
Source Mashhad University of Medical Sciences
Contact n/a
Is FDA regulated No
Health authority Iran: Ministry of Health
Study type Interventional

Clinical Trial Summary

Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date May 2006
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

- pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• metronidazole,doxycycline

Locations
Country Name City State
Iran, Islamic Republic of Mashhad University Of Medical Sciences(Dentistry School) Mashhad Khorasan

Sponsors (1)
Lead Sponsor Collaborator
Mashhad University of Medical Sciences

Country where clinical trial is conducted

Iran, Islamic Republic of, 

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