Clinical Trials Logo
  1. Home
  2. Oral Health
  3. NCT04178668

Molecular and Organizational Changes in the Human Oral Mucosa During Aging — MMOBUCC  

Oral Health Clinical Trial

Official title:
Molecular and Organizational Changes in the Human Oral Mucosa During Aging

Clinical Trial Summary

The objective of this interventional with mucosa et saliva samples, monocentric, transversal and pilot study is to extract vibrational, thermal and dielectric markers obtained by Differential Scanning Calorimetry, Thermo-Stimulated Currents and Fourier Transform Infrared spectroscopy on oral mucosa and saliva samples collected from 66 patients divided in two groups (20-40 and 70-90 years old).

Clinical Trial Description

Edentulism is prevalent in elderly people and the current care is the use of removable denture based on edentulous jaw regions. Nevertheless, the close and extended contact of denture base with mucosa and the transmission of chewing movement trough the complete denture leads to a weakening of supporting tissues in the medium to long term. This embrittlement may be accompanied by pain, compromising the proper integration of complete denture. In geriatrics, the peculiar weakness of bearing surfaces, connected to physio-pathological conditions as well as the decrease of adaptability and resistance further complicate the biomechanical integration of this kind of prosthesis. It has been shown that chronical ageing induces a decrease of resiliency and hydration of oral mucosa, associated with a decrease of epithelium thickness; nevertheless few studies have been performed at the molecular and supramolecular level to characterize this mucosa. Techniques of material characterization (Fourier transform Infrared spectroscopy, Differential scanning calorimetry (DSC), Thermostimulated currents (TSC), have shown their ability to follow hydric, molecular and structural modification of dermis upon ageing. In accordance with this study, the distribution of thermal, vibrational and dielectric markers of oral mucosa will be extracted in two age groups. The principal hypothesis of the research is the possibility to identify specific markers and to follow molecular and organizational changes induced by ageing (intrinsic ageing or extrinsic ageing due to prostheses wearing). The characterization of saliva by Fourier transform infrared spectroscopy (FTIR) shows promise in quantifying the biochemical components of this biofluid. Some vibrational saliva biomarkers have high diagnostic potential (physiological stress, diabetes, salivary lithiasis, carcinomas, periodontitis).This study is a first step to redefine the specification for the most appropriate biomaterial in removable prostheses. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04178668
Study type Interventional
Source University Hospital, Toulouse
Contact
Status Terminated
Phase N/A
Start date March 11, 2020
Completion date October 27, 2021
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06099574 - A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
Completed NCT00299598 - Clinical Study of Antibacterial Nanoparticles Incorporated in Composite Restorations Phase 2
Completed NCT00651248 - Evaluation of Salivary Flow and Buffer Capacity Associated to Aged People's Oral Health N/A
Completed NCT05046210 - The Effectiveness of Lay Health Advisors Strategy Intervention on Aborigines Elderly Oral Care Education N/A
Active, not recruiting NCT06457724 - Lactobacillus Brevis Oral Health N/A
Active, not recruiting NCT05124587 - Prediction for Critical Outcomes of Patients With COVID-19
Completed NCT03480516 - Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children N/A
Recruiting NCT04140929 - Oral Health Improvement for Nursing Home Residents Through Delegated Remotivation and Reinstruction N/A
Completed NCT05330793 - The Effects of an Oral Probiotic Intervention With or Without a Novel ADP-1 Toothpaste N/A
Completed NCT04289337 - Double-blind Clinical Trials of Probiotic Products in Oral Health. N/A
Not yet recruiting NCT06073392 - Cluster RCT on the Effect of the Topics Number in Oral Health Educational Video Among Preschool Children. N/A
Completed NCT00103493 - Oral Health Education Program Phase 3
Enrolling by invitation NCT06080672 - The Effect of Disclosing Dental Plaque on Plaque Index and Gingival Index in Faculty of Dentistry Students N/A
Completed NCT05755152 - Fruit-based Chewing Gums for Improving Oral Health N/A
Completed NCT05515510 - Acceptance and Efficacy of a Digital Application Among Parents to Control Early Childhood Caries N/A
Completed NCT03587428 - Effect of Two Toothpastes on Bacteria in Saliva N/A
Active, not recruiting NCT01514552 - The Use of Functional Confections in Promoting Oral Health Phase 1
Enrolling by invitation NCT06124222 - Prosthetic Rehabilitation and Its Influence on Masticatory Performance and QoL in Patients Treated for HNC N/A
Completed NCT05695443 - Oral Health in Prison: a Study on Improving Prisoners' Oral Health N/A
Completed NCT03141554 - The Effect of Oral Antiseptic Gargles on the Oral Cavity Microbiome Phase 4