Oral Glucose Tolerance Clinical Trial
Official title:
Acute Effects of Light and Dark Roasted Coffee on Glucose Tolerance: A Randomized, Controlled Crossover Trial in Healthy Volunteers
Verified date | December 2017 |
Source | University of Copenhagen |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Chlorogenic acid (CGA) in coffee may lower the postprandial glucose response. CGA is destroyed by dark roasting. In a controlled crossover trial, 11 healthy fasted volunteers consumed 300 mL of either light (LIR) or dark (DAR) roasted coffee, or water, followed 30 min later by a 75-g oral glucose tolerance test (OGTT). Plasma glukose and insulin, appetite, and plasma and urine metabolic profiles will be analysed. The primary aim is to investigate whether roasting affects the postprandial glucose area under the curve (AUC).
Status | Completed |
Enrollment | 11 |
Est. completion date | November 2015 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: Body mass index (BMI) of 18.0-30.0 kg/m2 and with no known diseases Exclusion Criteria: - systemic infections, - psychiatric or metabolic disorders, - known food allergies or intolerances related to the products used in the study (e.g. dairy or gluten), - ongoing or former drug abuse, - high intake of alcohol (defined as a weekly intake of >7 units for women and > 14 units for men), - pregnancy or ongoing planning of pregnancy, - vegetarianism or veganism, - participation in other scientific studies during the study period, and - blood donation during - or in the month leading up to - the study period |
Country | Name | City | State |
---|---|---|---|
Denmark | Department of Nutrition, Exercise and Sports, University of Copenhagen | Frederiksberg |
Lead Sponsor | Collaborator |
---|---|
University of Copenhagen |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Plasma glucose Area Under the Curve (Glucose AUC) | The area under the plasma glucose concentration curve was calculated from 0-120min after 75g glucose was ingested. | 0-120 min | |
Secondary | Plasma glucose concentrations | changes in the glucose concentration determined by a mixed model analysis and subsequently at each time point with time 0 as a co-variate. | 30, 60 and120 min | |
Secondary | Serum Insulin Area Under the Curve | Area under the curve (AUC) for serum insulin | 0-120 min | |
Secondary | Serum insulin concentrations | changes in the insulin concentration determined by a mixed model analysis and subsequently at each time point with time 0 as a co-variate. | 30, 60 and120 min | |
Secondary | ISI(0-120) | Matsuda's Insulin sensitivity index | 0-120min | |
Secondary | Metabolic profile in plasma | Metabolic profile of plasma measured in all samples collected before the meal and postprandially from 0-120 min as well as in samples collected up to 24 hrs later. | 0-24 hours | |
Secondary | Metabolic profile in urine | Metabolic profile of urine samples measured in all samples collected before the meal and postprandially from 0-120 min 120-240min as well as in samples collected up to 24 hrs later. | 0-24 hours |
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