the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as

Status Completed

Clinical Trial Summary

The purpose of the study is to determine if perineural dexmedetomidine can provide increased prolongation of analgesia when compared to perineural dexamethasone in patients receiving regional block for shoulder surgery. If so, dexmedetomidine may serve as a superior adjunct to peripheral nerve blocks in a rapidly evolving, ambulatory-centered surgical setting.

Clinical Trial Description

Currently, the most commonly employed adjunct to peripheral nerve blockade is perineural dexamethasone. In general, at the doses used in regional anesthesia, dexamethasone has a minimal side effect profile. However, while it has been shown to increase duration of analgesia, there have been concerns regarding its neurotoxicity in animal studies. In addition, dexamethasone has the potential to cause hyperglycemia in patients with impaired glucose metabolism as well as perineal pain and pruritis when administered peripherally.

Dexmedetomidine is a highly selective alpha-2 agonist that is commonly used in patients undergoing anesthesia or requiring sedation in a non-operative setting. As a peripherally administered medication, it has both sedating and analgesic properties, as well as the added benefit of avoidance of respiratory depression. Although it can rarely produce cardiac depression at high doses, its side effect profile is otherwise minimal and is generally very well tolerated by most patients. When administered peripherally, dexmedetomidine has most commonly been associated with side effects such as hypotension, respiratory depression, and bradycardia - although all at significantly higher doses than planned in our study. The safe use of perineural dexmedetomidine together with local anesthetics has been described on numerous occasions. Nevertheless, although it has been shown to potentiate peripheral nerve blockade and prolong duration of analgesia in various studies , it remains rarely used as an adjunct to regional anesthesia. ;

Study Design

Related Conditions & MeSH terms

Opioid Use, Unspecified

Clinical Trial Details

NCT number	NCT02653144
Study type	Interventional
Source	Montefiore Medical Center
Contact
Status	Completed
Phase	Phase 4
Start date	March 2016
Completion date	November 27, 2018

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06469177` - Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care	N/A
Terminated	`NCT02747875` - Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery	N/A
Completed	`NCT02244099` - Controlled Substance Treatment Agreements in an Internal Medicine Residents' Clinic	N/A
Completed	`NCT02282306` - Phone Interview to Prevent Recurring Opioid Overdoses	N/A
Recruiting	`NCT03923374` - Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes
Completed	`NCT04069403` - An Opioid Prescribing Nudge	N/A
Completed	`NCT04155229` - EMR Defaults to Nudge Opioid Prescribing	N/A
Completed	`NCT02299024` - Prescribing Opioid Pain Relievers in the Emergency Department: Understanding and Optimizing the Encounter	N/A
Recruiting	`NCT04564729` - Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing	N/A
Active, not recruiting	`NCT05283980` - Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement	Phase 2/Phase 3
Completed	`NCT04854551` - Opioid Modulation and Neural Reward Activation in Healthy Adults	Phase 1/Phase 2
Recruiting	`NCT06050551` - Pigtail or Chest Tube Placement After Uniportal Video-assisted Thoracoscopic Surgery	N/A
Completed	`NCT04928339` - Pecto-Intercostal Fascial Plane Block Study	Phase 4
Completed	`NCT03773484` - Application of Economics & Social Psychology to Improve Opioid Prescribing Safety (AESOPS): R21 Pilot Phase	N/A
Enrolling by invitation	`NCT05875857` - Patient Utilization of Opioid Destruction Bags in the Post op Period	N/A
Recruiting	`NCT04275258` - Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder	N/A
Completed	`NCT04252443` - Nurses' Knowledge and Attitude About Opioids	N/A
Recruiting	`NCT05242081` - Study on Opioid-free Anesthesia Protocol With S-ketamine and Propofol	N/A
Completed	`NCT02431793` - EHR‐Based Medication Complete Communication Strategy to Promote Safe Opioid Use	N/A
Completed	`NCT03959969` - Educational Video on Pain Management and Subsequent Opioid Use After Cesarean Delivery	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms