Clinical Trials Logo

Clinical Trial Summary

The aim of this study is to evaluate the efficacy and safety of argon-and nitrogen- non-thermal, atmospheric-pressure plasma (NTAPP) for reduction of sebum excretion in healthy volunteers with oily facial skin.


Clinical Trial Description

Excessive secretion of sebum contributes to several skin diseases associated with sebum glands, including acne. Excessive sebum secretion can damage the skin barrier function by changing the composition of skin surface lipids, leading to the abnormal keratinocyte differentiation and hyperkeratosis in the follicular ostia. Follicular hyperkeratosis can create anaerobic environment, leading to the proliferation of Propionibacterium acnes. Recently, several energy devices targeting sebaceous glands have been developed, but there is still a need for an effective and safe therapeutic tool for hyperseborrhea. Non-thermal, atmospheric-pressure plasma (NTAPP) has various biological effects. A recent study demonstrated NTAPP-induced microscopic tissue reactions in the sebaceous glands from rat skin in vivo, suggesting that the potential effect of NTAPP on the human sebaceous gland physiology, but the relevant data are lacking. In this study, investigators aim to assess the safety and efficacy of argon- and nitrogen-NTAPP for reduction of sebum excretion in oily human facial skin. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04917835
Study type Interventional
Source Gangnam Severance Hospital
Contact
Status Completed
Phase N/A
Start date November 15, 2019
Completion date May 6, 2020

See also
  Status Clinical Trial Phase
Completed NCT05138835 - BOTOX® Cosmetic and Skin Health. N/A
Completed NCT01640028 - Exploratory Study of Intra and Inter-subject Variability in Sebum Excretion Rate N/A
Completed NCT01254162 - Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers Phase 2
Completed NCT02597777 - Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin N/A