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Clinical Trial Summary

The purpose of this study is to analyze the relationship between sebum excretion rate and the following factors:

- Hormone levels (testosterone, dehydroepiandrosterone sulfate)

- Expression of 5-α-reductase type 1 (a protein in sebaceous glands that transforms a hormone (testosterone) into another one that strongly stimulates sebum production)

- Diet

- Sun and ultraviolet light exposure.

- Facial washing routine

- Sleep patterns (time when you start sleeping and total sleep time)

This study will analyze the relationship between sebum excretion rate and the various factors that may influence it in approximately 40 subjects. It will be conducted in one center located in Montreal. All devices are known and have already been used in the past.


Clinical Trial Description

A total of 40 subjects with a sebum excretion rate of at least 4 will be included. Subjects will be seen at Day 0 and Day 7. Casual sebum measurements will be performed at least 2 hours after washing the face in the morning with a Sebumeter® following a 30-second application of a Sebumeter® Measurement Cartridge to the forehead. Sebum excretion rates will be measured with Sebutape® applied to the right and left forehead at each visit. Each Sebutape® will be scanned and the area covered by sebum, seen as gray-black dots on the scanned Sebutape®, will be measured by an image analysis software. Circulating levels of free testosterone and DHEAS will be measured at each visit. A skin biopsy behind an ear will be performed at Day 0 and Day 7 to measure gene expression of the 5-α-reductase type 1. On Day 0 and Day 7, subjects will be required to take a 24-hour recall questionnaire. On Day 0 and Day 7, subjects will be questioned about the time of sleep induction, their total sleep time for the night preceding the visit, facial washing routine and the number of hours of direct and indirect UV exposure in the past 24 hours. On Day 0 and Day 7, subject's forehead skin temperature will be measured. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01640028
Study type Observational
Source Innovaderm Research Inc.
Contact
Status Completed
Phase N/A
Start date July 2012
Completion date December 2012

See also
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Completed NCT05138835 - BOTOX® Cosmetic and Skin Health. N/A
Completed NCT01254162 - Proof of Concept Study of MTC896 Gel to Reduce Sebum Production on the Forehead of Healthy Male Volunteers Phase 2
Completed NCT02597777 - Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin N/A