Ocular Melanoma Clinical Trial
Official title:
Exploratory Trial of Interferon Alpha-2b in Neoadjuvant Treatment of Ocular Melanoma
The purpose of this study is to explore whether the drug pegylated-interferon-alfa-2b (PEG-IFN) has any effect on a certain type of immune cell (called natural killer cells) in patients with eye melanoma.
The purpose of this study is to explore whether the drug pegylated-interferon-alfa-2b
(PEG-IFN)has any effect on a certain type of immune cell (called natural killer cells) in
patients with eye melanoma. Because this drug is currently being investigated for use
against skin melanoma, we think this drug might have some benefit in eye melanoma as well,
and that natural killer cells might be important in how the drug works.
Patients who choose to take part in the study will be randomized to receive either no drug,
or PEG-IFN. Four days prior to the patient's surgery to remove the eye, 50cc of blood will
be drawn. Patients who are randomized to PEG-IFN will be given the drug once, 4 days prior
to surgery. Blood will also be drawn on the day of surgery (50cc), 1 week after surgery
(50cc), 1 month (500cc), and 6 months (50cc).
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Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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