Metacognitive Therapy for Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder Clinical Trial

— MCTOCD  

Official title:

The Efficacy of Metacognitive Therapy for Obsessive-compulsive Disorder

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06466057
• Other study ID #: NENU2023032
• Status: Recruiting
• Phase: N/A
• Start date: June 11, 2024
• Est. completion date: November 1, 2024

Study information

• Verified date: June 2024
• Source: Northeast Normal University
• Contact: Fan Jiang, Ph.D
• Phone: 13943004788
• Email: Jiangf581[@]nenu.edu.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to learn if metacognitive therapy can be effective in a Chinese sample of obsessive compulsive disorder (OCD) . The main questions it aims to answer are:

Can metacognitive therapy significantly reduce participants' levels of obsessive-compulsive symptoms? Can metacognitive therapy significantly improve participants' metacognitive adaptations?

The researchers will compare metacognitive therapy to a control condition without psychotherapy to see if metacognitive therapy is effective in treating OCD.

Participants will:

Receive the metacognitive therapy intervention or under control conditions for 8 to 15 weeks.

Be assessed for symptoms and metacognitive beliefs at pre-intervention, post-intervention and 12 weeks post-intervention

Description:

This study will be a randomised controlled clinical trial. Participants who meet the enrolment criteria will be randomised into an experimental group and a control group. Participants in the experimental group will receive 8-15 weeks of metacognitive therapy, while participants in the control group will receive the same amount of time of regular treatment without psychotherapy components.

The researchers will assess participants' obsessive-compulsive symptoms and metacognitive levels before, after, and 12 weeks after the intervention. Assessment measures will be the Yale Brown Obsessive-Compulsive Scale (Y-BOCS) and the Metacognition Questionnaire (MCQ-30).

By comparing the assessment results of the two groups of participants, conclusions will be drawn as to whether metacognitive therapy can have a positive effect on a Chinese OCD sample.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: November 1, 2024
• Est. primary completion date: September 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years to 60 Years

Eligibility

Inclusion Criteria:

• two psychiatrists with the title of Deputy Chief Physician or above jointly determine that the above diagnostic criteria were met

• education level of junior high school or above, without mental retardation or audio-visual disorders

• participation in the study is voluntary, and the informed consent is signed by the patient or his/her guardian

Exclusion Criteria:

• loss of or insufficient self-awareness, the presence of hallucinations, delusions, and other psychotic symptoms

• the presence of severe depression, or self-inflicted suicidal attempts and behaviors

• the presence of a history of alcohol or drug abuse

• refusal of psychotherapy, or the ineffectiveness of those who had been involved in a full course of psychotherapy.

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

Intervention

Behavioral:
• Metacognitive Therapy
A one-on-one face-to-face dialogue format will be used to conduct psychotherapy with each participant, and the treatment protocol will be based on the treatment manual for metacognitive therapy.

Other:
• General mental health promotion
A general mental health mission will be conducted, not covering any metacognitive therapy related content, set for 8-15 weeks, 1 time per week

Locations

Country	Name	City	State
China	Northeast Normal University	Changchun	Jilin

Sponsors (1)

Lead Sponsor	Collaborator
Northeast Normal University

Country where clinical trial is conducted

China, 

References & Publications (2)

Fisher PL, Wells A. Metacognitive therapy for obsessive-compulsive disorder: a case series. J Behav Ther Exp Psychiatry. 2008 Jun;39(2):117-32. doi: 10.1016/j.jbtep.2006.12.001. Epub 2007 Mar 7. — View Citation

Wells A, Capobianco L, Matthews G, Nordahl HM. Editorial: Metacognitive Therapy: Science and Practice of a Paradigm. Front Psychol. 2020 Sep 18;11:576210. doi: 10.3389/fpsyg.2020.576210. eCollection 2020. No abstract available. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Severity of participants' obsessive-compulsive symptoms	Assessed using the Yale Brown Obsessive-Compulsive Scale (Y-BOCS) , with higher scores indicating more severe symptoms.	Pre-intervention to 12 weeks post-intervention
Secondary	Levels of Participants' Dysfunctional Metacognitive Beliefs	Assessed using the Metacognition Questionnaire (MCQ-30), with higher scores being associated with more dysfunctional metacognition.	Pre-intervention to 12 weeks post-intervention

External Links

•   It contains a specific intervention process for metacognitive therapy
•   It contains the basic concepts of metacognitive therapy