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Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure — ERP in Silico  

Obsessive-Compulsive Disorder Clinical Trial

Official title:
Cognitive and Neural Networks in Psychiatry (CNNP): Neural Mechanisms of Obsessive-compulsive Disorder (OCD) Treatment Failure (ERP in Silico)

Clinical Trial Summary

The aim of this study is to understand why patients with obsessive-compulsive disorder (OCD) fail in therapy. To understand the neural mechanisms involved in exposure therapy that support success and clinical improvement in order to improve therapy outcomes for OCD patients.

Clinical Trial Description

A course of therapy is recommended for individuals with obsessive-compulsive disorder (OCD). It is usually a type of cognitive behavioural therapy (CBT) with exposure and response prevention (ERP). In this study the investigators assess patients pre-therapy and post-therapy evaluating symptom severity (measured by the Y-BOCS) and decision-making (measured by online questionnaires and computer-based behavioural tasks). To examine how decisions are formed in patients undergoing OCD CBT, how behaviour changes after a non-pharmacological therapy module and how it is associated to the alleviation of OCD symptoms. The study, which will recruit 90 patients, is based at University College London - Wellcome Centre for Human Neuroimaging. This study is a part of the Cognitive and Neural Networks in Psychiatry (CNNP) study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05520398
Study type Observational
Source University College, London
Contact Karen Hoang, MSc
Phone +44-(0)203-1087538
Email k.hoang@ucl.ac.uk
Status Recruiting
Phase
Start date November 10, 2021
Completion date December 31, 2025
View Details
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