Neural Correlates of Compulsivity

Obsessive-Compulsive Disorder Clinical Trial

Official title:

Neural Correlates of Compulsivity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05195476
• Other study ID #: 7867
• Status: Completed
• Start date: December 17, 2021
• Est. completion date: February 28, 2024

Study information

• Verified date: May 2024
• Source: Columbia University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology and healthy individuals. Behavioral and electroencephalogram (EEG) data will be collected during one experimental reinforcement learning tasks from participants diagnosed with OCD (n = 30) and healthy controls (n = 30). Computational modeling, an advanced data analytic approach that can directly link neural measures with behavior, will be used to quantify learning processes. These parameters then will be related to measures of neural events obtained using EEG, a neuroimaging method that has high temporal resolution, to test for evidence of neurocognitive alterations.

Description:

Learning and decisions making are thought to be directed by multiple parallel cognitive systems. These systems account for automatic, inflexible responding to stimuli, as well as more deliberate, effortful representations of relationships in an environment. It has long been suggested than an imbalance in these cognitive control systems explains the emergence of compulsivity, a trait in which behaviors persist despite adverse outcomes. Compulsivity is a characteristic of a number of psychological disorders, however, current theories of how abnormalities in cognitive systems involved in learning and decision making lead to the onset of these disorders remain incomplete.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 41
• Est. completion date: February 28, 2024
• Est. primary completion date: February 28, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Between 18-50 years of age

• English-speaking

• Capacity to provide informed consent

• Primary diagnosis of OCD with at least moderate severity

Exclusion Criteria:

• Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation

• History of any significant medical condition that may increase the risk of participation

• Alcohol or substance use disorder in the past year

• Exposure and response prevention for OCD within the last six weeks

• Currently taking psychotropic medication

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

Locations

Country	Name	City	State
United States	New York State Psychiatric Institute	New York	New York

Sponsors (2)

Lead Sponsor	Collaborator
Columbia University	International OCD Foundation

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neural Activity	EEG will be recorded while participants complete computerized reinforcement learning tasks at one study visit	One-time study visit