EEG Results of Deep TMS in Patients With OCD

Obsessive-Compulsive Disorder Clinical Trial

Official title:

Electrophysiological Results of the Efficacy of Deep Transcranial Magnetic Stimulation on Mood State and Quality of Life in Obsessive Compulsive Disorder Patients

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05188833
• Other study ID #: EEG.DeepTMS.OCD
• Status: Active, not recruiting
• Phase: N/A
• Start date: May 17, 2020
• Est. completion date: May 2022

Study information

• Verified date: October 2021
• Source: Istanbul Medipol University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Obsessive Compulsive Disorder (OCD) is a psychiatric disorder in which involuntary thoughts and irresistible behaviors are seen and its prevalence affects 2%-3% of the general population. Deep TMS is a treatment method that provides stimulation of lower parts of the brain and larger brain volume, and in addition to drug treatment and psychotherapy approaches, magnetic stimulation of localized brain regions and disease symptoms are addressed. The presence of the medial prefrontal cortex and anterior cingulate cortex in the dysfunction on the specified cycle seen in OCD patients indicates that the stimulation of these regions is necessary for a meaningful result in the treatment of deep TMS; studies show that the effect of the deep TMS method emerges as a result of the stimulation of these regions. 30 patients with OCD will included into the study and dividen into 3 groups (DTMS (n=10), DTMS + Paroxetine (n=10), Control(n=10)). Patients will evaluated in terms of depression, quality of life, and EEG before and after the intervention.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 30
• Est. completion date: May 2022
• Est. primary completion date: October 20, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Being diagnosed with Obsessive Compulsive Disorder within the framework of DSM-5 criteria

Exclusion Criteria:

• Not volunteering to comply with the research program

• Presence of a metal piece on the head

• Having a pacemaker inserted

• Having had a previous epileptic seizure

Related Conditions & MeSH terms

• EEG With Periodic Abnormalities
• Obsessive-Compulsive Disorder

Intervention

Device:
• Deep Transcranial Magnetic Stimulation
Deep TMS, unlike traditional TMS, is a treatment method that provides stimulation of lower parts of the brain and larger brain volume, in addition to drug treatment and psychotherapy approaches, in addition to localized brain regions magnetic stimulation is a treatment method where disease symptoms are addressed.

Drug:
• Paroxetine
Paroxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It's often used to treat depression.

Locations

Country	Name	City	State
Turkey	Istanbul Medipol University	Istanbul	Beykoz

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul Medipol University Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Electroencephalography	It is an electrophysiological neuroimaging method frequently used in neuroscience and clinic, in which the activity between neural circuits can be measured and observed non-invasively in the form of electrical waves.	6 weeks after baseline
Secondary	Beck Depression Scale	It is the scale used for evaluated the level of depression. Higher score means worse result.	6 weeks after baseline
Secondary	World Health Organization Quality of Life Scale Short Form	It is the scale used for evaluated the level of quality of life. It contains a total of 26 questions. Higher score means better result.	6 weeks after baseline