Overlapping Neural Circuits in Pediatric OCD

Status Completed

Clinical Trial Summary

The purpose of this study is to examine the brain functioning of children and adolescent with OCD before and after treatment with Exposure and Response Prevention (EXRP) therapy.

Clinical Trial Description

The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. The investigators will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using pediatric OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future trans-diagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new trans-diagnostic treatments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02421315
Study type	Interventional
Source	New York State Psychiatric Institute
Contact
Status	Completed
Phase	N/A
Start date	October 2014
Completion date	September 30, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04631042` - Developing Brain, Impulsivity and Compulsivity
Completed	`NCT02855580` - Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic
Completed	`NCT02229903` - An Evaluation of the Safety and Efficacy of the dTMS Treatment for OCD	N/A
Completed	`NCT02202915` - CBT for Pediatric OCD: Community Training Pilot	N/A
Completed	`NCT01794156` - Evaluation of a Cognitive Therapy (Inference-based-therapy) for the Treatment of Obsessional Compulsive Disorder	N/A
Completed	`NCT02089984` - Web Based Therapist Training on Cognitive Behavior Therapy for Anxiety Disorders	N/A
Completed	`NCT01348529` - Internet Cognitive Behavior Therapy (CBT) for Obsessive Compulsive Disorder (OCD)	N/A
Recruiting	`NCT00965211` - Evaluation of the HBDL Coil Transcranial Magnetic Stimulation (TMS) Device - Safety and Feasibility Study for the Treatment of Tourette Syndrome	N/A
Completed	`NCT00723060` - Comparison of Effects Between Conventional Dose and High Dose Escitalopram on Clinical Improvement in Patients With Obsessive-compulsive Disorder	Phase 4
Not yet recruiting	`NCT00743834` - Cost-Effectiveness of Adding Web-Based Cognitive-Behavioral Therapy (CBT) to Luvox CR for Obsessive Compulsive Disorder (OCD)	Phase 4
Completed	`NCT01172873` - D-Cycloserine Augmentation to CBT With Exposure and Response Prevention in Adults and Adolescents With OCD	N/A
Completed	`NCT02194075` - Methylphenidate Hydrochloride Controlled-Release Tablets Augmentation Strategy for Patients With Obsessive Compulsive Disorder	Phase 4
Completed	`NCT01981317` - Stepped Care Cognitive Behavioral Therapy for Pediatric Obsessive Compulsive Disorder	N/A
Completed	`NCT01686087` - Attaining and Maintaining Wellness in Obsessive-compulsive Disorder	N/A
Terminated	`NCT00997087` - A Randomized, Double-Blind, Placebo-Controlled Trial of Flumazenil for the Treatment of Obsessive Compulsive Disorder	Phase 2
Completed	`NCT01331876` - Modification of Cerebral Activity of Obsessive Compulsive Disorder (OCD) Patients During Cognitive and Behavioral Therapy	N/A
Completed	`NCT00533806` - Comparing the Effectiveness of Two Family-based Therapies in Treating Young Children With Obsessive-Compulsive Disorder	Phase 3
Completed	`NCT00517244` - Evaluating Parenting Styles and Child Temperament Associated With Child Anxiety Disorders	N/A
Completed	`NCT00169377` - Subthalamic Nucleus (STN) Stimulation and Obsessive-Compulsive Disorder (OCD)	Phase 1/Phase 2
Completed	`NCT00116532` - Escitalopram for the Treatment of Obsessive Compulsive Disorder (OCD)	Phase 4