Control and Reward Circuits in Obsessive Compulsive Disorder

Obsessive-Compulsive Disorder Clinical Trial

Official title:

Control & Reward Circuits as Targets for Repetitive Thoughts and Behaviors

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02221518
• Other study ID #: #7000/R01MH104648-01
• Status: Completed
• Phase: N/A
• Start date: October 2014
• Est. completion date: August 2018

Study information

• Verified date: March 2019
• Source: New York State Psychiatric Institute
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.

Description:

The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: August 2018
• Est. primary completion date: June 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria for Patients:

• Male and females with OCD aged 18-55

• Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Diagnosis of OCD

• Not on psychotropic medication

Exclusion Criteria for Patients:

• Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging

• Comorbid psychiatric conditions that significantly elevate the risk of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality)

• Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)

• Use of psychotropic medication

• Females who are pregnant or post-menopausal

Inclusion Criteria for Healthy Volunteers

• Male and females aged 18-55

Exclusion Criteria for Healthy Volunteers

• Presence of metallic devices or dental braces in the body that are contraindicators for MR imaging

• Any psychiatric diagnosis

• Use of psychotropic medication

• Diagnosis of OCD in a first degree relative

• Females who are pregnant or post-menopausal

• Unstable medical conditions that need attention and would make participation in the study unsafe (e.g. very high blood pressure)

Related Conditions & MeSH terms

• Obsessive-Compulsive Disorder

Intervention

Behavioral:
• Exposure & Response Prevention (EX/RP)
Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD.

Locations

Country	Name	City	State
United States	NY State Psychiatric Institute	New York	New York

Sponsors (1)

Lead Sponsor	Collaborator
New York State Psychiatric Institute

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline in brain activation (fMRI) and fractional anisotropy (Diffusion tensor imaging) after therapy		Baseline & approximately 10 weeks later
Secondary	Change in reaction times and correct responses on Stop signal reaction time task		Baseline and approximately 10 weeks later, at second scan