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Control and Reward Circuits in Obsessive Compulsive Disorder

Obsessive-Compulsive Disorder Clinical Trial

Official title:
Control & Reward Circuits as Targets for Repetitive Thoughts and Behaviors

Clinical Trial Summary

The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.

Clinical Trial Description

The capacity to coordinate thoughts and actions to execute goal-directed behaviors (cognitive control) and the capacity to anticipate, respond to, and learn from reward (reward processing) are key processes for human behavior. Dysfunction in these processes has been hypothesized to contribute to repetitive thoughts and behaviors in many disorders, including obsessive-compulsive disorder (OCD), Tourette Syndrome (TS), and eating disorders. We will use multimodal imaging to investigate neural circuits that support cognitive control and reward processing, using OCD as a model system. The short-term goal is to clarify how circuit-based abnormalities contribute to repetitive thoughts/behaviors; these data will inform future transdiagnostic studies. The long-term goal is to identify control and reward circuit-abnormalities as targets for new transdiagnostic treatments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02221518
Study type Interventional
Source New York State Psychiatric Institute
Contact
Status Completed
Phase N/A
Start date October 2014
Completion date August 2018
View Details
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