Obese Clinical Trial
Official title:
The Effects of Short Term Growth Hormone Treatment on Skeletal Muscle Phosphocreatine Recovery in Obesity
Obesity is associated with reduced growth hormone (GH) secretion. Reduced GH secretion in obesity is associated with increased cardiovascular disease risk. However, it is not yet known how reduced GH increases cardiovascular disease risk in obesity. The investigators hypothesize that reduced GH contributes to dysfunction of the mitochondria. Therefore, the investigators hypothesize that treatment of obese subjects with reduced GH secretion with GH will improve mitochondrial function and that this improvement in mitochondrial function will contribute, in part, to the effects of GH to improve metabolic parameters in obesity. The investigators propose to study skeletal muscle mitochondria in obese subjects with reduced GH secretion using magnetic resonance spectroscopy and muscle biopsies before and after treatment with GH.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04105075 -
COPD in Obese Patients
|
||
Completed |
NCT04099654 -
The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery
|
N/A | |
Recruiting |
NCT05857150 -
Exercise Response in Humans With Obesity
|
||
Completed |
NCT03532672 -
Early Effect of Fasting on Metabolic, Inflammatory, and Behavioral Responses in Females With and Without Obesity
|
N/A | |
Completed |
NCT02086448 -
Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)
|
N/A | |
Completed |
NCT02618486 -
The Effects of Obesity on Non Surgical Periodontal Therapy
|
N/A | |
Completed |
NCT01724502 -
Mitochondrial Dysfunction in Diabetes
|
N/A | |
Completed |
NCT01724515 -
PGC-1 and Mitochondrial Dysfunction in Diabetes
|
N/A | |
Active, not recruiting |
NCT01634204 -
Efficacy of a Web-based Weight Loss Program
|
Phase 2 | |
Completed |
NCT01479933 -
Glucose Metabolism Effects of Vitamin D Supplementation in Prediabetes
|
N/A | |
Completed |
NCT01467817 -
Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)
|
N/A | |
Completed |
NCT03528304 -
Native Women's Wellness: Contingency Management for Tobacco Cessation and Weight Loss
|
N/A | |
Completed |
NCT01726647 -
Metabolism Associated With Abdominal Fat Mass Distribution
|
N/A | |
Active, not recruiting |
NCT02125149 -
The Expecting Study
|
N/A | |
Completed |
NCT05737927 -
Pharmacodynamics and Pharmacokinetics of Different Glucose Bead Formulations in Obese Healthy Subjects
|
Phase 1 | |
Completed |
NCT05433506 -
Safety and Pharmacokinetics of HU6
|
Phase 1 | |
Completed |
NCT02871882 -
Ox Bile- Conjugated Bile Acids Sodium in Type II Diabetes Mellitus
|
Phase 2 | |
Completed |
NCT03298464 -
Study of NGM313 in Obese Participants
|
Phase 1 | |
Completed |
NCT05061173 -
Comparison of Aerobic, Resistance, and Combined Training in Overweight/Obese Hypertensive Adults
|
N/A | |
Completed |
NCT02919176 -
Brown Fat Activation Study
|
Early Phase 1 |