Nutritional Requirements Clinical Trial
Official title:
Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children
Iodine as an essential trace element for human, both excessive and insufficient intake would be harmful for human health. As susceptible population, children will be more sensitive to adverse effects caused by inadequate intake of iodine since they are at the peak of growth and development. Meanwhile, there are few direct evidence to establish dietary intakes levels of iodine for 3-6 years old pre-school children.
Status | Recruiting |
Enrollment | 2650 |
Est. completion date | December 31, 2026 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 3 Years to 6 Years |
Eligibility | Inclusion Criteria: - for children with mild malnutrition: hemoglobin <110g / L, or weight for age <P50 according to the Chinese 2009 child growth and development reference standard, or BMI z score <-1 according to the WHO Child Growth Assessment Software (version 3.2.2 ) ; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history. - for children with good nutritional status: healthy,-1 <BMI z score <1; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history; Exclusion Criteria: long-term low-protein; long-term low-heat energy malnutrition |
Country | Name | City | State |
---|---|---|---|
China | Shandong Institute for Endemic Disease Control and Research | Yuncheng | Shandong |
Lead Sponsor | Collaborator |
---|---|
Chen Wen | Shandong Institute for Endemic Disease Control and Research |
China,
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* Note: There are 29 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | urinary iodine concentration | µg/L | 2 weeks | |
Primary | diet iodine intake | µg/day | 2 weeks | |
Primary | urinary iodine excretion | µg/day | 2 weeks | |
Primary | thyroglobulin antibody | IU/mL | 2 weeks | |
Primary | salt iodine concentration | µg/L | 2 weeks | |
Primary | water iodine intake | µg/day | 2 weeks | |
Primary | thyroid volume | ml | 2 weeks |
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