Nutritional Requirements Clinical Trial
Official title:
Effects of Vitamin D on Skeletal Muscle Strength in Resistance Trained Adult Females
The majority of vitamin D research has been done in non-athletic populations, particularly older populations, to analyze muscle weakness, pain, balance, and fractures. It has been reported that over a billion people worldwide are vitamin D deficient, including 36-70% of the young adult population. Previous literature also suggests that, even among healthy athletes, over 50% of subjects sampled had inadequate or insufficient vitamin D levels. Vitamin D deficiency can occur in young women, including pregnant women, and the risk of deficiency is even higher with advancing age in a woman's lifecycle. It is known that preserving skeletal muscle (SM) function is critical for women of all ages to prevent sarcopenia. Two factors in preserving SM are protein intake and resistance training. Relatively unknown are the actions of Vitamin D on SM function. Vitamin D deficiency can have a negative effect on SM function . However, additional research is needed to investigate the increase in SM strength when the serum concentration of vitamin D is improved. It is possible that an athlete may require an increased intake of vitamin D to assure adequate availability and storage for optimal performance; however, is known that food sources of vitamin D are limited in sufficient quantity to meet these requirements. Athletes who are insufficient will require a supplement of vitamin D3 for up to 5000 IU/day for at least eight weeks, to potentially reach optimal levels, then 1000-2000 IU/day for maintenance.
Status | Not yet recruiting |
Enrollment | 40 |
Est. completion date | February 1, 2023 |
Est. primary completion date | November 30, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 19 Years to 55 Years |
Eligibility | Inclusion criteria will include: Participant will need to answer "yes" to the following items: 1. female 2. not pregnant 3. between the ages of 19-55 years old 4. a non-smoker 5. currently resistance training (i.e., lifting weights) for more than 2 days/week for a minimum of > 24 months 6. free of any known overt cardiovascular or metabolic disease 7. not an active user of tanning beds 8. not consuming now or haven't consumed within the last 6 months, a vitamin D or multivitamin supplement or a form of a supplement with vitamin D added 9. not consuming now or haven't consumed within the last 2 months, agents that affect hormones (testosterone boosters, growth hormone boosters, etc.) (does not include birth control/oral contraceptives) 10. not allergic to rubbing alcohol Exclusion criteria will include: 1) Outside of study inclusion parameters |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Auburn University |
Abrams GD, Feldman D, Safran MR. Effects of Vitamin D on Skeletal Muscle and Athletic Performance. J Am Acad Orthop Surg. 2018 Apr 15;26(8):278-285. doi: 10.5435/JAAOS-D-16-00464. Review. — View Citation
Bartoszewska M, Kamboj M, Patel DR. Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am. 2010 Jun;57(3):849-61. doi: 10.1016/j.pcl.2010.03.008. Review. — View Citation
Chiang CM, Ismaeel A, Griffis RB, Weems S. Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review. J Strength Cond Res. 2017 Feb;31(2):566-574. doi: 10.1519/JSC.0000000000001518. Review. — View Citation
Dahlquist DT, Dieter BP, Koehle MS. Plausible ergogenic effects of vitamin D on athletic performance and recovery. J Int Soc Sports Nutr. 2015 Aug 19;12:33. doi: 10.1186/s12970-015-0093-8. eCollection 2015. Review. — View Citation
de la Puente Yagüe M, Collado Yurrita L, Ciudad Cabañas MJ, Cuadrado Cenzual MA. Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients. 2020 Feb 23;12(2). pii: E579. doi: 10.3390/nu12020579. Review. — View Citation
Han Q, Li X, Tan Q, Shao J, Yi M. Effects of vitamin D3 supplementation on serum 25(OH)D concentration and strength in athletes: a systematic review and meta-analysis of randomized controlled trials. J Int Soc Sports Nutr. 2019 Nov 26;16(1):55. doi: 10.11 — View Citation
Knechtle B, Nikolaidis PT. Vitamin D and Sport Performance. Nutrients. 2020 Mar 21;12(3). pii: E841. doi: 10.3390/nu12030841. — View Citation
Ksiazek A, Zagrodna A, Slowinska-Lisowska M. Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes-A Narrative Review. Nutrients. 2019 Aug 4;11(8). pii: E1800. doi: 10.3390/nu11081800. Review. — View Citation
Ogan D, Pritchett K. Vitamin D and the athlete: risks, recommendations, and benefits. Nutrients. 2013 May 28;5(6):1856-68. doi: 10.3390/nu5061856. Review. — View Citation
Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011 Mar;22(3):859-71. doi: 10.1007/s00198-010-1407-y. Epub 2010 Oct 6. Review. — View Citation
Tomlinson PB, Joseph C, Angioi M. Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with meta-analysis. J Sci Med Sport. 2015 Sep;18(5):575-80. doi: 10.1016/j.jsams.2014.07.022. — View Citation
Wicinski M, Adamkiewicz D, Adamkiewicz M, Sniegocki M, Podhorecka M, Szychta P, Malinowski B. Impact of Vitamin D on Physical Efficiency and Exercise Performance-A Review. Nutrients. 2019 Nov 19;11(11). pii: E2826. doi: 10.3390/nu11112826. Review. — View Citation
* Note: There are 12 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Biodex Strength performance change | Taking a daily supplement of 5,000 IU of vitamin D3 may change strength outcomes measured in newton meters (Nm). | 8 weeks | |
Secondary | Serum 25(OH)D status | Taking a daily supplement of 5,000 IU of vitamin D3 may change blood levels of vitamin D. | 8 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00803699 -
Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels
|
N/A | |
Completed |
NCT03279315 -
An Iodine Balance Experiment
|
N/A | |
Recruiting |
NCT06074770 -
Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children
|
||
Completed |
NCT00292812 -
Clinical Effects of a Nucleotides-Supplemented Infant Formula
|
N/A | |
Recruiting |
NCT04287816 -
Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 1
|
N/A | |
Active, not recruiting |
NCT04286321 -
Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 2
|
N/A | |
Completed |
NCT04419103 -
Study on Physiologic Requirement and Dietary Recommended Nutrient Intake (RNI) of Iodine in Children
|
||
Recruiting |
NCT04492657 -
Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
|
||
Not yet recruiting |
NCT05730803 -
Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation
|