Nutritional Requirements Clinical Trial
Official title:
Study on the Compensatory Mechanism of Iodine Nutrition and the Optimal Intake Level of Lactating Women
Due to the lack of direct evidence of optimal iodine intake of Chinese children, pregnant and lactating women and infants were found during the recent revision of Chinese dietary reference intakes (DRIs) of iodine in 2013 by the applicant Pro. Zhang, and no systematical research about compensatory mechanism of iodine nutrition in lactating women was found yet. Previous study funded by United Nations International Children's Emergency Fund (UNICEF) cooperated with the international experts on iodine and key project of national natural science foundation of China under the guidance of Pro. Zhang, had obtained the safe intake range of iodine from children and pregnant women, more than 10 joint papers were published, which laid the foundation of population study and international cooperation.
Studies indicate lactating women and their infants are the most vulnerable population to the
adverse effects of iodine deficiency and excess, and because of the complexity of the study
of lactating mothers and infants and the difficulty of sample collection, it is proposed to
overcome this problem with the help of the advanced dried blood spot technique and iodine
balance study method from the panel of Iodine Global Network (IGN). Investigators intend to
recruit 900 late pregnant women in Tianjin, Hebei and Shandong;then establishing a dynamic
cohort of breastfeeding mother-infant to 6 months after delivery to investigate the
physiological compensatory mechanism of iodine nutrition in lactating women with the
combination of animal experiment; On the other hand, 180 exclusively breastfeeding mother and
infants within postpartum 0-6 months, will be selected to participate the iodine balance
study.
Optimized method of iodine balance experiment of infants by both foreign partner and Pro.
Zhang's team will be adopted to obtain the first iodine balance value of Chinese lactating
women and infants,providing the direct evidence for the revision of DRIs in lactating women
and infants, and guide the lactating women proper iodine supplementation to meet the
requirements of both mothers and infants.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05489666 -
Effects of Vitamin D on Skeletal Muscle Strength in Resistance Trained Adult Females
|
N/A | |
| Completed |
NCT00803699 -
Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels
|
N/A | |
| Completed |
NCT03279315 -
An Iodine Balance Experiment
|
N/A | |
| Recruiting |
NCT06074770 -
Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children
|
||
| Completed |
NCT00292812 -
Clinical Effects of a Nucleotides-Supplemented Infant Formula
|
N/A | |
| Recruiting |
NCT04287816 -
Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 1
|
N/A | |
| Active, not recruiting |
NCT04286321 -
Achieving Nutritional Adequacy Of Vitamins E and K With An Egg/Plant-Based Food Pairing - Study 2
|
N/A | |
| Completed |
NCT04419103 -
Study on Physiologic Requirement and Dietary Recommended Nutrient Intake (RNI) of Iodine in Children
|
||
| Not yet recruiting |
NCT05730803 -
Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation
|