Nutrition Disorders Clinical Trial
Official title:
Diet, Intestinal Microbiota and Metabolomics: Evaluation of Possible Synergies
It is widely known that the quality of the diet is able to modify the expression of many
bacterial genes populating the intestine of the host, as well as the type of bacteria
themselves. This is also expressed with a more or less evident and troublesome after meals
symptomatology that many patients complain to the health care staff.
A good composition of the microbiota is crucial for the health of the individual, both at the
intestinal level as well as at the systemic level because, depending on the type of food
substrate available at the intestinal level, metabolites will be produced capable of
positively or negatively affect the health of the individual.
In fact, scientific evidence shows the existence of the causal link between the health of the
microbiota and the genesis of inflammatory diseases not only intestinal, but also systemic,
and even of cancer, obesity, metabolic syndrome and atherosclerosis.
The recent diffusion of gene sequencing techniques has brought significant developments in
the study of the human and bacterial genome, which allow to produce enormous quantities of
sequences at a lower cost and at a higher speed than previous techniques.
Therefore the clinical Nutrition Clinic of the IRCCS De Bellis in Castellana Grotte (BA)
proposes to check if changes in the intestinal microbiota correlate, not only with
anthropometric and clinical-laboratory parameters, but also with the typical symptoms of
irritable bowel syndrome (IBS), a functional pathology very widespread with the advent of the
modern era, in which, a diet rich in sugars and proteins of animal origin and poor in plant
foods, is unfortunately common also in the areas of the Mediterranean basin.
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