Continuous Versus Intermittent Enteral Feeding in Critically Ill Patients

Nutrition Disorders Clinical Trial

Official title:

Continuous Versus Intermittent Enteral Feeding in Critically Ill Patients: a Prospective, Randomized Controlled Trial

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02159456
• Other study ID #: feed520
• Status: Active, not recruiting
• Phase: N/A
• Start date: May 2014
• Est. completion date: December 2021

Study information

• Verified date: August 2021
• Source: Seoul National University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

1. Nutritional support during critical illness is important to improve the clinical outcome of patients. Recently, the apply of early enteral nutrition is recommend in critically ill patients on basis of data that enteral nutrition can be helpful to prevent the hospital-acquired infections.

• However, in critically ill patients, the smooth progress of nutritional support is often hindered by gastrointestinal intolerance, underlying clinical condition, and temporal necessity of procedure or operation.

• Continuous feeding method, compared with intermittent feeding, is expected to reduce the risk of gastrointestinal intolerance, and improve the nutritional support, but this hypothesis is not supported by appropriate evidences.

2. We will elucidate to compare the efficacy and safety of the continuous feeding method in critically ill patients, compared with the intermittent feeding method.

• Prospective, randomized controlled study

• Primary outcome: the achievement rate of target nutritional goal within 7 days after the start of enteral nutrition

• Secondary outcome: gastrointestinal tolerance, In-ICU/hospital mortality, frequency of hospital-acquired infection, ICU/hospital length-of-stay, duration of mechanical ventilation

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 70
• Est. completion date: December 2021
• Est. primary completion date: December 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• adult patient admitted in the intensive care unit

• age 20 years old or more

• The enteral nutritional support is expected to be available within 48 hours after ICU admission

Exclusion Criteria:

• previous abdominal surgery within 1 month

• gastrointestinal bleeding, bowel obstruction, refractory vomiting/diarrhea

• hypersensitivity to prokinetics, history of seizure or phechromocytoma

• enteral feeding via enterostomy or gastrostomy

• difficulty to insert or maintain nasogastric tube

• need for specialized feeding (ex: hemodialysis diet, chronic renal failure diet, diabetes diet)

• pregnancy

Related Conditions & MeSH terms

• Nutrition Disorders

Intervention

Other:
• Continuous enteral feeding via infusion pump

• Intermittent enteral feeding via gravity-based infusion

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul	Daehak-ro, Jongno-gu

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Achievement rate of target nutritional goal		Within 7 days after the start of enteral feeding
Secondary	Gastrointestinal tolerance		Within 7 days after start of enteral feeding
Secondary	ICU/hospital mortality		During hospital admission
Secondary	Frequency of hospital-aquired infection		During hospital admission
Secondary	ICU/hospital length-of-stay		During hospital admission
Secondary	Duration of mechanical ventilation		During hospital admission