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The Efficacy and Safety of KN046 Combined With Axitinib

NSCLC Clinical Trial

Official title:
Study on the Efficacy and Safety of KN046 Combined With Acitinib as a Neoadjuvant Therapy in Resectable Stage IB-IIIB Non-small Cell Lung Cancer (NSCLC) Patients

Clinical Trial Summary

Evaluation of the efficacy of KN046 combined with acitinib as a neoadjuvant therapy for resectable NSCLC through primary pathological response rate and surgical resection rate

Clinical Trial Description

The purpose of this study is to evaluate the rate of major pathological remission (MPR) with preoperative use of KN046 versus axitinib, and thus to assess the efficacy of KN046 in combination with axitinib in patients with Stage IB-IIIB (Stage IIIB only T3N2M0) NSCLC (according to the 8th edition of the AJCC classification) who are scheduled to undergo surgery. Eligible subjects for this study were candidates for surgery for resectable stage IB-IIIB (stage IIIB only T3N2M0) NSCLC as judged by the investigator, with no evidence of distant metastases as assessed, and no evidence of unresectable local regional tumour extension. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06020352
Study type Interventional
Source Shanghai Pulmonary Hospital, Shanghai, China
Contact Chang Chen, Dr
Phone 65115006
Email 2031222@tongji.edu.cn
Status Recruiting
Phase Phase 2/Phase 3
Start date August 25, 2023
Completion date July 1, 2025
View Details
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