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Pembrolizumab, Lenvatinib and Chemotherapy After TKIs in NSCLC

Nsclc Clinical Trial

Official title:
A Phase 2 Open-label Single-arm Study to Evaluate the Combination of Pembrolizumab, Lenvatinib and Chemotherapy in Non-small Cell Lung Cancer (NSCLC) Harbouring Targetable Mutation and Failed Standard Tyrosine Kinase Inhibitors

Clinical Trial Summary

Adding chemotherapy or anti-VEGF to immunotherapy is an emerging strategy to enhance the efficacy of immunotherapy in many cancers. This phase 2 study aims to explore the preliminary efficacy of combination pembrolizumab with lenvatinib and chemotherapy in NSCLC patients with sensitizing EGFR, ALK, or ROS1 genetic aberration refractory to standard targeted therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04989322
Study type Interventional
Source The University of Hong Kong
Contact Dr Joanne Chiu, MBBS
Phone +852-22553111
Email jwychiu@hku.hk
Status Recruiting
Phase Phase 2
Start date October 5, 2021
Completion date December 2024
View Details
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