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Drug Concentration Monitoring of Pembrolizumab in Non-Small Cell Lung Cancer Patients — Oncomabs  

NSCLC Clinical Trial

Official title:
Drug Concentration Monitoring of Pembrolizumab in Treatment-naive Non-Small Cell Lung Cancer Patients

Clinical Trial Summary

This observational study explores associations between drug trough-levels and clinical outcomes in Non Small Cell Lung Cancer (NSCLC) patients treated with immunotherapy (pembrolizumab) either alone or combined with chemotherapy. Through-levels of pembrolizumab will be examined in blood samples collected during the first-line treatment period. In addition T-cell responses in peripheral blood and anti-drug antibodies will be monitored. Results of drug trough-levels and T-cell responses will be linked to clinical outcome. 250 patients with NSCLC will be enrolled in this trial.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04557007
Study type Observational
Source Oslo University Hospital
Contact Ragnhild Nome, MD
Phone +4798602658
Email ragnom@ous-hf.no
Status Recruiting
Phase
Start date September 1, 2020
Completion date October 1, 2025
View Details
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