NSCLC Stage IV Clinical Trial
Official title:
Optimizing the Therapeutic Dose of Apatinib Mesylate Tablets in Patients With Lung Cancer by Dose Titration:A Real World Exploratory Study
The purpose of the study is to evaluate the safety and efficacy of two different administration methods of apatinib in NSCLC patients.
1. Aged ≥18;
2. Locally advanced/metastatic non-small lung cancer (IIIb/IV) confirmed by pathology with
measurable lesions;
3. Patients with wild type EGFR/ALK must received two kinds of systemic chemotherapy
before;Patients with EGFR mutation positive had experienced treatment failure with TKI
in first line and Chemotherapy in second line ;
4. ECOG:0-4;
5. The subjects were treated with other drugs has been restored (NCI CTCAE version 4.0
class 1 or less), which accept nitroso urea or mitomycin interval 6 weeks or more;
Accept other cytotoxic drugs, bevacizumab (Avastin) (except local palliative
radiotherapy), radiotherapy or surgery four weeks or more. EGFR TKI ≥2 weeks; Main
organs function is normal;
6. Fertile woman must perform a pregnancy test (serum or urine) 7 days before screened, or
voluntarily adopt proper methods of contraception during the observation period and 8
week after the last given apatinib. For man, surgical sterilization should be performed,
or voluntarily adopt proper methods of contraception during the observation period and 8
week after the last given apatinib;
7. Patients voluntarily entered the study and signed informed consent form (ICF).
;
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