Nosocomial Infection Clinical Trial
Official title:
Bacterial Eradication of the Nasal Epithelium From Infectious Toxins With PDT (BENEFIT-PDT)
This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute care hospital for a wide range of surgical procedures.
The purpose of the proposed study is to gather data regarding the safety and efficacy of nasal photodisinfection treatment in eliminating colonization of the anterior nares with S. aureus. The anterior nares are often considered the primary reservoir of S. aureus and other pathogens on the body, therefore, this product could play an important role in helping to eliminate this pathogen reservoir in patients. Since photodisinfection is a non-antibiotic approach that does not generate antibiotic resistance, this could be a beneficial approach to achieving nasal disinfection. Additionally, photodisinfection has an extremely broad spectrum of activity and is effective against bacterial, viral, and fungal pathogens including emerging pathogens such as C. auris. This is a Phase 2 study. Nasal cultures will be performed on all patients admitted for surgery at Memorial Health University Medical Center over a 1-month period. This will determine the prevalence rate of S. aureus and other pathogens in community patients who are being admitted for surgery. The results of this culture will not be known to the research staff until several days later. Clinical trial subjects will universally receive a nasal disinfection treatment followed by a post-treatment culture. This will demonstrate the efficacy of nasal disinfection against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03365635 -
Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis C
|
Phase 4 | |
| Recruiting |
NCT05904535 -
Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections
|
||
| Completed |
NCT01704430 -
Glutamine to Improve Outcomes in Cardiac Surgery
|
N/A | |
| Terminated |
NCT01225159 -
Tight Glycaemic Control During Cardiac Surgery
|
N/A | |
| Recruiting |
NCT04659356 -
NOSOcomial COVID-19 in ICU (NOSOCOVID)
|
||
| Terminated |
NCT03423147 -
Preoperative Application of Chlorhexidine to Reduce Infection With Cesarean Section After Labor
|
Phase 2 | |
| Completed |
NCT03429283 -
Achromobacter Xylosoxidans (ACHX) Infections
|
||
| Recruiting |
NCT04252651 -
Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients
|
||
| Completed |
NCT04405934 -
COG-UK Project Hospital-Onset COVID-19 Infections Study
|
N/A | |
| Active, not recruiting |
NCT03865706 -
Inulin for Infections in the Intensive Care Unit
|
Phase 2 | |
| Recruiting |
NCT05411562 -
COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations
|
||
| Completed |
NCT03250104 -
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
|
||
| Completed |
NCT00864929 -
An Epidemiological Study on Antimicrobial Treatment of Nosocomial Infections in Clinical Practice
|
N/A | |
| Completed |
NCT01763008 -
A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections
|
Phase 4 | |
| Terminated |
NCT01515020 -
Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia
|
Phase 3 | |
| Active, not recruiting |
NCT05511129 -
Tolerance and Efficacy of Amiklin Administration During Nosocomial Infections Complicating COVID-19 in the ICU
|
||
| Completed |
NCT04212130 -
Can Environmental Cleanliness be Assessed by BCA (Bicinchoninic Acid) Method
|
N/A | |
| Active, not recruiting |
NCT05988853 -
Biosafety of Musical Instruments in the ICU
|
||
| Recruiting |
NCT01943331 -
Epidemiological Investigation of CRBSI, VAP, CAUTI in Chinese ICU
|
N/A | |
| Completed |
NCT00105625 -
VA Nutrition Study on Immune Function
|
N/A |