| Eligibility |
Key Inclusion Criteria:
To be eligible for this study, subjects must meet all the following:
1. In stable and good general health, without significant medical illness, based on
medical history, physical examination, and vital signs at screening based on
investigator judgement.
2. Body mass index (BMI) between >/= 17.0 and </= 35.0 kg/m2 at screening SNG.
3. Available for all planned visits and tele-health appointment, and willing to complete
all protocol-defined procedures and assessments (including ability and willingness to
swallow multiple small enteric-coated tablets per study dose).
4. Female subjects must not be breastfeeding and must provide a negative pregnancy test
at screening and pre-dose.
5. Female subjects must fulfill one of the following criteria:
i. At least 1 year post-menopausal (defined as amenorrhea for greater than or equal to
12 consecutive months prior to screening without alternative medical cause) or
surgically sterile.
ii. Female subjects of childbearing potential must be willing to use a highly
effective form of contraception for 30 days prior to initial vaccination and until 60
days after last vaccination. Acceptable forms are oral, implantable, intrauterine,
transdermal, intravaginal, injectable, double barrier or abstinence (subjects using
diaphragms must also use condom). The form of contraception must be approved by the
investigator.
iii. Male subjects must agree to practice abstinence from heterosexual intercourse or
to use an effective method of birth control as noted above from first vaccination to
60 days after last vaccination. Male subjects must agree to refrain from donating
sperm and practice abstinence from all intercourse or to use an effective method of
double barrier birth control or condom as noted above from first vaccination to 60
days after last vaccination.
6. Capable of understanding and giving signed informed consent which includes compliance
with the requirements and restrictions listed in the ICF and in the protocol.
Key Exclusion Criteria:
The subjects must be excluded from participating in the study if they meet any of the
following:
1. Known clotting/bleeding issues and/or personal and family history with increased risk
of bleeding or clotting.
2. Presence of significant uncontrolled medical or psychiatric illness (acute or chronic)
including institution of new medical/surgical treatment or significant dose alteration
for uncontrolled symptoms or drug toxicity within 3 months prior to screening and
reconfirmed at baseline.
3. Cancer, or treatment for cancer or any procedure or preventive medication for cancer
or to prevent recurrence, within past 3 years (excluding fully treated and resolved
basal cell carcinoma or squamous cell carcinoma)
4. Presence of immunosuppression or medical condition possibly associated with impaired
immune responsiveness, including diabetes mellitus- type 1 and 2
5. History of irritable bowel disease or other inflammatory digestive or gastrointestinal
condition that could affect the distribution/safety evaluation of an orally
administered vaccine targeting the mucosa of the small intestine. Such conditions may
include but are not limited to:
a. Any history of: i. GI malignancy ii. malabsorption iii. pancreatobiliary disorders
iv. inflammatory bowel disease v. irritable bowel disease vi. hiatal hernia vii.
surgical resection b. History of diagnosis or treatment in past 5 years of: i.
esophageal or gastric motility disorder ii. gastro esophageal reflux disorder iii.
peptic ulcer iv. cholecystectomy
6. History of any form of angioedema
7. History of serious reactions to vaccination such as anaphylaxis, respiratory problems,
hives or abdominal pain
8. Diagnosed bleeding disorder or significant bruising or bleeding difficulties that
could make blood draws problematic.
9. Any condition that resulted in the absence or removal of the spleen
10. Acute disease within 72 hours prior to vaccination defined as the presence of a
moderate or severe illness (as determined by the investigator through medical history
and physical exam). (Assessment may be repeated once during Screening Period)
11. Presence of a fever greater than or equal to 38°C measured orally at baseline.
12. Any significant hospitalization within the last year which in the opinion of the
investigator or sponsor could interfere with study participation.
13. Any history or conditions that may lead to higher risk of clotting events and/or
thrombocytopenia:
1. Family or personal history of bleeding or thrombosis.
2. History of heparin-related thrombotic events, and/or receiving heparin
treatments.
3. History of autoimmune or inflammatory disease.
4. Presence of any of the following conditions known to increase risk of thrombosis
within 6 months prior to screening:
i. Recent surgery other than removal/biopsy of cutaneous lesions ii. Immobility
(confined to bed or wheelchair for 3 or more successive days) iii. Head trauma with
loss of consciousness or documented brain injury iv. Receipt of anticoagulants for
prophylaxis of thrombosis v. Recent clinically significant infection, including
hospitalization for COVID-19 infection.
14. Any other condition that in the clinical judgement of the investigator would
jeopardize the safety or rights of a subject taking the study drug, would render the
subject unable to comply within the protocol or would interfere with the evaluation of
the study endpoints diagnostic assessments.
15. Positive human immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg) or
Hepatitis C virus (HCV) tests at the screening visit.
16. History of GI bleeding including hematochezia (blood in stool) or melena (black stool)
17. Positive urine drug screen for drugs of abuse at screening (positive test for
marijuana is not exclusionary; however concurrent use of marijuana during the study
Active period through Day 29 is prohibited).
18. Positive breath or urine alcohol test at screening and baseline.
19. Receipt of a licensed vaccine (including any COVID-19 vaccines under emergency use
authorization) within 14 days prior to baseline vaccination or planned administration
during the study active period (Day 29).
20. Use of antibiotics, proton pump inhibitors, H2 blockers or antacids within 7 days
prior to study drug administration or planned use during the active study period (Day
29).
21. Use of medications known to affect the immune function (e.g., including but not
limited to systemic corticosteroids, leukotriene modifiers, and JAK inhibitors) within
2 weeks before study drug administration or planned use during the active study period
(Day 29).
22. Daily use of nonsteroidal anti-inflammatory drugs within 7 days prior to study drug
administration or planned use during the active study period (Day 29). Low dose daily
ASA less than or equal to 100 mg for cardio-protection is not exclusionary.
23. Administration of any investigational vaccine, drug or device within 8 weeks preceding
study drug administration, or planned use within the duration of the study
24. Previous participation in a Vaxart Clinical Trial or other NoV vaccine trial unless
confirmed receipt of placebo.
25. Donation or use of blood or blood products within 30 days prior to study drug
administration or planned donation during the active study period (Day 29).
26. History of drug, alcohol, or chemical abuse within 1 year of screening.
27. History of hypersensitivity or allergic reaction to any component of the
investigational vaccine, including but not limited to fish gelatin allergy.
|
