Normal Volunteers Clinical Trial
Official title:
Optimization of Novel DCE-MRI Imaging Sequences for Cancer Therapy Monitoring
This pilot clinical trial studies dynamic contrast enhanced (DCE)-magnetic resonance imaging (MRI) in diagnosing cancer. New diagnostic procedures, such as DCE-MRI may help find and diagnose cancer
PRIMARY OBJECTIVES:
I. Optimize and develop functional DCE-MRI pulse sequences, which involve the injection of
MRI-visible contrast agents, for imaging in the head/neck, abdominal and pelvic regions.
II. Determine the ideal radiofrequency (RF) coil setup to maximize signal to noise ratio of
the optimized pulse sequences.
III. Distill the findings of specific aims 1 and 2 into streamlined protocols that can be
used in subsequent studies for cancer phenotyping and treatment monitoring in a quantitative
manner.
IV. To establish a virtual reference image repository for future studies.
OUTLINE: Patients undergo DCE-MRI over approximately 30-60 minutes consisting of an
anatomical scout image to localize the region of interest, a set of pre-injection scans to
calibrate the dynamic image set, a dynamic image set during which contrast agent will be
injected, and a set of post-injection scans to calibrate the DCE-MRI database.
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