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Normal Volunteers clinical trials

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NCT ID: NCT03993587 Completed - Normal Volunteers Clinical Trials

The Effect of Head and Shoulder Positioning on the Cross-sectional Area of the Subclavian Vein in Obese Adults

Start date: August 20, 2019
Phase:
Study type: Observational

In the present study, the cross-sectional area of subclavian vein, and the depth of the SCV from the skin are assessed in different head positions (neutral, rotation to ipsilateral or contralateral sides) and different shoulder positions (neutral or lowered) in spontaneous breathing obese adults.

NCT ID: NCT02922946 Completed - Healthy Volunteers Clinical Trials

Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat

Start date: October 11, 2016
Phase: Phase 1
Study type: Interventional

The objectives of this study are to evaluate the effect of the timing of a moderate-fat meal on the single dose pharmacokinetics of entinostat and to evaluate the safety and tolerability of entinostat under fed and fasting conditions in healthy adult subjects.

NCT ID: NCT02922933 Completed - Healthy Volunteers Clinical Trials

A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Entinostat in Healthy Adult Subjects

Start date: October 25, 2016
Phase: Phase 1
Study type: Interventional

The purpose of this study is therefore to evaluate the effect of concomitant drugs through an increase of intra-gastric pH levels on the bioavailability of entinostat. The primary objectives of this study are to evaluate the effect of multiple doses of omeprazole, famotidine, and the effect of an acidic beverage in combination with omeprazole on the single-dose PK profile of entinostat. The secondary objectives are to evaluate the safety and tolerability of a single dose of entinostat when administered with multiple doses of omeprazole, famotidine, and when administered with an acidic beverage in combination with omeprazole.

NCT ID: NCT02860351 Completed - Normal Volunteers Clinical Trials

The Effect of Head Positioning on the Cross-sectional Area of the Subclavian Vein.

Start date: August 10, 2016
Phase: N/A
Study type: Observational

In the present study, the cross-sectional area of subclavian vein, the distances of subclavian vein ~ subclavian artery and subclavian vein ~ pleura are assessed in different head positions (neutral, rotation to ipsilateral or contralateral sides) in spontaneous breathing adults.

NCT ID: NCT02828813 Completed - Cognition Disorders Clinical Trials

Neural Mechanisms of Motor and Cognitive Networks

Start date: June 2016
Phase:
Study type: Observational

This study investigates the neural mechanisms of motor and cognitive networks using cognitive assessment, reaction time measurement, high-density EEG and fMRI.

NCT ID: NCT02517307 Completed - Normal Volunteers Clinical Trials

Fatty Acid Oxidation Defects and Insulin Sensitivity

Start date: February 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the normal range. The investigators want to know if having one of the fatty acid oxidation disorders could have an influence on insulin action. Fatty acid oxidation disorders are genetic disorders that inhibit one of the enzymes that converts fat into energy. The investigators will study both normal healthy people and people with a long-chain fatty acid oxidation disorder.

NCT ID: NCT02146391 Completed - Normal Volunteers Clinical Trials

Study to Evaluate the Effect of Food Upon the Pharmacokinetics of Androxal

Start date: June 2014
Phase: Phase 1
Study type: Interventional

This study is an open-label, randomized, single-center, single-dose, two-way crossover study of the PK properties of Androxal in healthy male subjects. Twelve male subjects will each receive a single dose of Androxal 25 mg in both the fed and fasting state.

NCT ID: NCT02113943 Completed - Normal Volunteers Clinical Trials

Double Blind Randomized, Monocentric, Cross-over, Placebo-controlled Study to Evaluate the Effect of Citalopram on Motivation

MBBCitalopram
Start date: April 2014
Phase: Phase 2
Study type: Interventional

The aim of the current study is to examine the role of serotonin on the cognitive parameters of motivation. They are embedded in a conceptual framework of motivation that merges decision-making and reinforcement learning theories. Every action is conceived as path from one state to another. The different states are associated to different values (positive for rewards and negative for punishments), and the different actions to different costs (risk, effort and delay). The tasks are designed such that the sensitivity to the state and action parameters can be inferred by fitting computational models.The primary objective is to characterize the effect of Citalopram 30mg on reward sensitivity, assessed in an incentive force task, in which participants are asked to squeeze a hand grip to win monetary rewards. Secondary objectives are to characterize the effect of Citalopram 30mg on other cognitive parameters of motivation (assessed with a motivational battery that includes rating, choice and learning tasks).

NCT ID: NCT02051517 Completed - Normal Volunteers Clinical Trials

Vitreous Chemistry Analysis

Start date: May 2013
Phase: N/A
Study type: Observational

The aim of this study is to expand the understanding of the vitreous, its solute chemistry, and the normal relationship of that chemistry to the chemistry of the systemic circulation in humans. Sample human vitreous from patients undergoing vitrectomy surgery and compare to results of metabolic chemistry panel from subject. Allow the research team to extract .2ml sample of the .5ml - 1.0ml vitreous that is normally extracted during a routine undiluted vitreous biopsy, a standard procedure performed for various indications. Blood draw for metabolic chemistry panel (1-2 ml).

NCT ID: NCT01366352 Completed - Normal Volunteers Clinical Trials

Pharmacokinetics and Bioavailability Comparison of Two Different Formulations of MNTX Tablets

Start date: February 2004
Phase: Phase 1
Study type: Interventional

This was a single-center, double-blind, randomized, cross-over Phase 1 study in normal, healthy volunteers. Study treatment entailed single doses of two different formulations of MNTX tablets.