Clinical Trials Logo
  1. Home
  2. Normal Pressure Hydrocephalus
  3. NCT03877107

Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH — PLHPN  

Normal Pressure Hydrocephalus Clinical Trial

Official title:
Effect of Depletive Lumbar Puncture and Cerebrospinal Fluid Shunt Surgery on Lower Urinary Tract Dysfunction in Normal Pressure Hydrocephalus

Clinical Trial Summary

Lower urinary tract dysfunction in normal pressure hydrocephalus has received little attention from the scientific community. Urinary symptoms in normal pressure hydrocephalus are mainly represented by overactive bladder, which is a significant burden for the concerned patients. A harmonization of neuro-urological practices in the pre-therapeutic evaluation of patients suffering from normal pressure hydrocephalus is necessary.

The investigators conducted a bicentric prospective study aiming to evaluate the effect of depletive lumbar puncture on urinary symptoms in iNPH.

The secondary objective was to evaluate, in the same participants previously diagnosed, the effect of cerebrospinal fluid shunt surgery on urinary symptoms.

Clinical Trial Description

Prospective study interventional but non invasive Bicentric in two universitarian hospitals in France On a cohort of patients presenting at least two out of three symptoms of the classic triad (urinary symptoms, cognitive symptoms and gait disturbance) and enlargement of ventricles non explained by cortical atrophy.

Participants are offered, as routine care, a diagnostic evaluation of the effect of depletive lumbar puncture on these triad symptoms (this exam is part of routine care).

Before the planned lumbar puncture, the participants are requested to participate to the study, with written consent and information given. The participants are requested to fill in a USP (urinary symptoms profile, validated international questionnaire) questionnaire and a micturition calendar. The same urinary evaluation is made 5 days after lumbar puncture. Gait and cognition are evaluated as in routine practice.

Of the participants initially evaluated, some will be proposed shunt surgery (routine care). These participants will be proposed to fill in the same questionnaire and micturition calendar around 3 months after shunt surgery (post operative evaluation). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03877107
Study type Interventional
Source University Hospital, Grenoble
Contact Jean Alexandre LONG, MD PHD
Phone +334 76 76 76 42
Email JALong@chu-grenoble.fr
Status Recruiting
Phase N/A
Start date March 13, 2019
Completion date March 1, 2021
View Details
See also
  Status Clinical Trial Phase
Terminated NCT00149721 - Anterior Pituitary Function in Patients With Hydrocephalus N/A
Completed NCT00196196 - A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System. Phase 3
Not yet recruiting NCT05562596 - Normal Pressure Hydrocephalus Biomarkers Investigation
Completed NCT00233701 - Normal Pressure Hydrocephalus (NPH) Registry Phase 4
Unknown status NCT00874198 - European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus N/A
Withdrawn NCT00793416 - ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Phase 4
Recruiting NCT05910944 - European Study of Prodromal iNPH
Active, not recruiting NCT01909960 - Flow MRI in Normal Pressure Hydrocephalus N/A
Completed NCT02016352 - Cerebrospinal Fluid Proteome in Hydrocephalus N/A
Terminated NCT01092546 - Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus Phase 3
Terminated NCT00613886 - Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus N/A
Completed NCT01815775 - Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery Phase 0
Enrolling by invitation NCT03269201 - Brain Network Activation in Patients With Movement Disorders
Recruiting NCT03245138 - Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus N/A
Terminated NCT00727142 - Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH) N/A
Recruiting NCT04471740 - Normal Pressure Hydrocephalus and Sleep Apnea N/A
Completed NCT01798641 - A Randomized Cross-over Study for Normal Pressure Hydrocephalus N/A
Recruiting NCT01618500 - Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus N/A
Completed NCT00600795 - Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus N/A
Terminated NCT03521518 - CPT-3 in Normal Pressure Hydrocephalus