Normal Pressure Hydrocephalus Clinical Trial
— HydroFluxOfficial title:
Benefit of Flow Magnetic Resonance Imaging in the Management of Normal Pressure Hydrocephalus
Verified date | August 2018 |
Source | Centre Hospitalier Universitaire, Amiens |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging.
Status | Active, not recruiting |
Enrollment | 144 |
Est. completion date | September 2018 |
Est. primary completion date | September 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Ventricular dilation seen on morphological magnetic resonance imaging (MRI) - Walking disorder - Cognitive disorder - Participants gave their written informed consent Exclusion Criteria: - Contra-indication to MRI - Obstructive tumoral hydrocephalus - Curatorship or tutorship - Pregnancy or lactation - No social assurance |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens | Amiens | Picardie |
France | CHU Lille | Lille | Nord Pas De Calais |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire, Amiens |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | cerebrospinal fluid (CSF) stroke volume evolution other 6 months | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution | Day 1 (baseline), Day 180 | |
Secondary | Blood flow analysis : evolution other 6 months | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. | Day 1 (baseline), Day 180 | |
Secondary | Larson's score evolution over 6 months | Record symptoms on walking, living conditions and urinary disorders | Day 1, Day 180 | |
Secondary | Neuropsychological test evolution over 6 months | Consists in mini mental status evaluation (MMSE) for cognitive evaluation | Day1, Day 180 | |
Secondary | Blood flow analysis : evolution other one year | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. | Day 1 (baseline) and Day 365 | |
Secondary | Larson's score evolution over one year | Record symptoms on walking, living conditions and urinary disorders | Day 1 and Day 365 | |
Secondary | Neuropsychological test evolution over one year | Consists in mini mental status evaluation (MMSE) for cognitive evaluation | Day1, Day 365 | |
Secondary | cerebrospinal fluid (CSF) stroke volume evolution other one year | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution | Day1 (baseline), Day 365 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT00149721 -
Anterior Pituitary Function in Patients With Hydrocephalus
|
N/A | |
Completed |
NCT00196196 -
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
|
Phase 3 | |
Not yet recruiting |
NCT05562596 -
Normal Pressure Hydrocephalus Biomarkers Investigation
|
||
Completed |
NCT00233701 -
Normal Pressure Hydrocephalus (NPH) Registry
|
Phase 4 | |
Unknown status |
NCT00874198 -
European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus
|
N/A | |
Withdrawn |
NCT00793416 -
ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients
|
Phase 4 | |
Recruiting |
NCT05910944 -
European Study of Prodromal iNPH
|
||
Completed |
NCT02016352 -
Cerebrospinal Fluid Proteome in Hydrocephalus
|
N/A | |
Terminated |
NCT01092546 -
Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
|
Phase 3 | |
Completed |
NCT01815775 -
Predictive Value of Flow MRI in Normal Pressure Hydrocephalus Surgery
|
Phase 0 | |
Terminated |
NCT00613886 -
Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
|
N/A | |
Recruiting |
NCT03877107 -
Effect of Depletive Lumbar Puncture on Lower Urinary Tract Dysfunction in iNPH
|
N/A | |
Enrolling by invitation |
NCT03269201 -
Brain Network Activation in Patients With Movement Disorders
|
||
Recruiting |
NCT03245138 -
Endoscopic Third Ventriculostomy Versus Ventriculo-peritoneal Shunting in Idiopathic Normal Pressure Hydrocephalus
|
N/A | |
Terminated |
NCT00727142 -
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
|
N/A | |
Recruiting |
NCT04471740 -
Normal Pressure Hydrocephalus and Sleep Apnea
|
N/A | |
Completed |
NCT01798641 -
A Randomized Cross-over Study for Normal Pressure Hydrocephalus
|
N/A | |
Recruiting |
NCT01618500 -
Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
|
N/A | |
Completed |
NCT00600795 -
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
|
N/A | |
Terminated |
NCT03521518 -
CPT-3 in Normal Pressure Hydrocephalus
|