Nonalcoholic Steatohepatitis Clinical Trial
Official title:
Non-invasive Evaluation of Liver Fibrosis, Steatosis, and Nonalcoholic Steatohepatitis in Biopsy-Proven NAFLD Patients
1. To evaluate hepatic fibrosis and steatosis using MR imaging, transient elastography
(TE), and serum biomarker
2. To develop non-invasive diagnosis marker for NASH and advanced fibrosis
As nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver
disease, non-invasive diagnosis of disease severity in NAFLD is urgently needed. In this
study, the investigators compared hepatic fibrosis and steatosis using MR imaging and
transient elastography (TE) and tried to find non-invasive diagnostic marker for NASH and
advanced fibrosis.
This is a multicenter prospective study of patients with biopsy-proven NAFLD. The patients
were underwent laboratory test, liver biopsy, MRI and TE within 6 months of enrollment. MRI
examination included MR spectroscopy (MRS), and MR elastography (MRE). TE measured liver
stiffness and controlled attenuation parameter (CAP).
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