Non Ulcer Dyspepsia Clinical Trial
Official title:
Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia
The purpose of this study is to determine if use of Nortriptyline will improve symptoms and quality of life in patients who have nonulcer dyspepsia.
Nonulcer dyspepsia is a common complaint in clinical practice and its management should be
based on the best evidence. Many clinical trials of nonulcer dyspepsia suffer from important
weaknesses in trial design. This makes it difficult to determine whether truly efficacious
therapies exist for this disorder.
Once a diagnosis of nonulcer dyspepsia is confirmed by normal endoscopy, a trial of therapy
is commonly prescribed. However, the benefits of all therapies in this condition have been
questioned. Small studies have suggested benefit in use of antidepressants such as
Nortriptyline and even though the data is insufficient, antidepressants such as
Nortriptyline are widely used in clinical practice largely due to lack of proven, reliable
therapies for nonulcer dyspepsia.
Our hypothesis is that Nortriptyline will improve symptoms of nonulcer dyspepsia and improve
quality of life.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00132171 -
Helicobacter Pylori Eradication With a New Sequential Treatment
|
Phase 3 |