Genetic Basis of Odor Discrimination

Non-smokers Clinical Trial

Official title:

Genetic Basis of Odor Discrimination

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01039935
• Other study ID #: LVO-0684
• Status: Completed
• Phase: N/A
• First received: December 23, 2009
• Last updated: September 5, 2012
• Start date: November 2009
• Est. completion date: August 2012

Study information

• Verified date: September 2012
• Source: Rockefeller University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 512
• Est. completion date: August 2012
• Est. primary completion date: August 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

1. Age 18-50

2. Current non-smokers

Exclusion Criteria:

1. Current smokers

2. Allergy to fragrances or smells of any kind

3. Active head cold, upper respiratory infection, or seasonal nasal allergies

4. History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.

5. Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Non-smokers

Locations

Country	Name	City	State
United States	The Rockefeller University	New York	New York

Sponsors (1)

Lead Sponsor	Collaborator
Rockefeller University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors		3 years	No
Secondary	concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors		3 years	No