| Eligibility |
Inclusion Criteria:
1. Clinical or pathological diagnosis of early resectable NSCLC stage I-II (AJCC version
7).
2. Have measurable tumor of a least one cm in its largest diameter.
3. Clinically assessed to be a candidate for curative intent lobectomy or larger
procedure (e.g. bilobectomy, pneumonectomy, lobectomy with segmentectomy, etc).
4. Is willing to undergo a procedure aimed to collect tumor tissue for pathologic
diagnosis and for research correlative studies.
5. Be willing and able to provide written informed consent/assent for the trial.
6. Be > 18 years of age on day of signing informed consent.
7. Have a performance status of 0 or 1 on the ECOG Performance Scale.
8. Demonstrate adequate organ function as defined in Table 1, all screening labs should
be performed within 10 days of treatment initiation.
Table 1: Adequate Organ Function Laboratory Values System Laboratory Value
Hematological Absolute neutrophil count (ANC) >=1,500 /mcL Platelets>=100,000 / mcL
Hemoglobin>= 9 g/dL or >=5.6 mmol/L RenalSerum creatinine OR Measured or calculated
creatinine clearance (GFR can also be used in place of creatinine or CrCl) <=1.5 X
upper limit of normal (ULN) OR >=60 mL/min for subject with creatinine levels > 1.5 X
institutional ULN Hepatic Serum total bilirubin <=1.5 X ULN OR Direct bilirubin <= ULN
for subjects with total bilirubin levels > 1.5 ULN AST (SGOT) and ALT (SGPT) <= 2.5 X
ULN OR Coagulation International Normalized Ratio (INR) or Prothrombin Time (PT)
Activated Partial Thromboplastin Time (aPTT) = 1.5 X ULN unless subject is receiving
anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use
of anticoagulants <=1.5 X ULN unless subject is receiving anticoagulant therapy as
long as PT or PTT is within therapeutic range of intended use of anticoagulants
aCreatinine clearance should be calculated per institutional standard.
9. Female subject of childbearing potential should have a negative urine or serum
pregnancy within 72 hours prior to receiving the first dose of study medication. If
the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
will be required.
10. Female subjects of childbearing potential should be willing to use 2 methods of birth
control or be surgically sterile, or abstain from heterosexual activity for the course
of the study through 120 days after the last dose of study medication (Reference
Section 5.7.2). Subjects of childbearing potential are those who have not been
surgically sterilized or have not been free from menses for > 1 year.
11. Male subjects should agree to use an adequate method of contraception starting with
the first dose of study therapy through 120 days after the last dose of study therapy.
Exclusion Criteria:
1. Severe lung emphysema with a significantly elevated risk of dangerous complications
from a biopsy of a lung lesion.
2. Predicted post-operative (PPO)-FEV1 or PPO-DLCO < 30% (as calculated based on
patient's age, sex, weight, height and planned operation).
3. Has a known diagnosis of immunodeficiency or is receiving systemic steroid therapy or
any other form of immunosuppressive therapy within 7 days prior to the first dose of
trial treatment.
4. Has had a prior monoclonal antibody within 4 weeks prior to study Day 1 or who has not
recovered (i.e., <= Grade 1 or at baseline) from adverse events due to agents
administered more than 4 weeks earlier.
5. Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
(besides as part of a curative treatment for a different malignancy, completed 5 years
or more prior recruitment to study).
6. Has a known additional active malignancy. Exceptions include basal cell carcinoma of
the skin, squamous cell carcinoma of the skin, low grade bladder TCC or in situ
cervical cancer that has undergone potentially curative therapy. History of other
malignancies can be permitted provided at least five years have passed since the
completion of a potentially curative therapy.
7. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment. Subjects with vitiligo or resolved childhood asthma/atopy
would be an exception to this rule. Subjects that require intermittent use of
bronchodilators or local steroid injections would not be excluded from the study.
Subjects with hypothyroidism stable on hormone replacement or Sjorgen's syndrome will
not be excluded from the study.
8. Has evidence of interstitial lung disease or active, non-infectious pneumonitis.
9. Has an active infection requiring systemic therapy.
10. Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the trial, interfere with the subject's
participation for the full duration of the trial, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator.
11. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
12. Is pregnant or breastfeeding, or expecting to conceive or father children within the
projected duration of the trial, starting with the pre-screening or screening visit
through 120 days after the last dose of trial treatment.
13. Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or
anti-Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including
ipilimumab or any other antibody or drug specifically targeting T-cell co-stimulation
or checkpoint pathways).
14. Has a known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies).
15. Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA
[qualitative] is detected).
16. Has a known history of active TB (Bacillus Tuberculosis).
17. Has received a live vaccine within 30 days prior to the first dose of trial treatment.
|
