Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer Clinical Trial

Official title:

A Phase I Trial of Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05785845
• Other study ID #: 202302003
• Status: Recruiting
• Phase: N/A
• Start date: April 10, 2023
• Est. completion date: October 31, 2027

Study information

• Verified date: April 2024
• Source: Washington University School of Medicine
• Contact: Pamela Samson, M.D., MPHS
• Phone: 314-801-3806
• Email: psamson[@]wustl.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity. Online adaptive radiation therapy was until recently only done clinically on an integrated MRI-guided system, but recently, Varian Medical Systems has created a CT-guided radiotherapy machine capable of online adaptive radiotherapy (ETHOS). The vast majority of stereotactic body radiotherapy (SBRT) for early-stage lung cancers is performed on a CT-guided machine rather than an MRI-guided machine, necessitating the evaluation of adaptive radiotherapy using ETHOS in this population. Historically, the non-adaptive, stereotactic treatment of central and ultra-central thoracic disease has been associated with unacceptable rates of grade 3+ toxicity. This has resulted in widespread adoption of a hypofractionated, less ablative 8-15 day treatment courses, with a baseline, one-year grade 3+ toxicity rate of 20%. Use of CT-STAR with daily, CT-guided plan adaptation to carefully spare adjacent organs-at-risk (OAR) in this setting may enable safe delivery of a shorter (5 fraction) and more ablative radiotherapy course.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 17
• Est. completion date: October 31, 2027
• Est. primary completion date: October 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Histologically or radiographically diagnosed stage I-IIA (AJCC, 8th ed.) non-small cell lung cancer or mediastinal recurrent non-small cell lung cancer with plans to be treated with definitive intent SBRT alone.
• Clinical AJCC stage I defined as stage 1A1 (T1a1N0M0, T1a tumor less than or equal to 1 cm), stage 1A2 (T1bN0M0, T1b tumor between 1 and 2 cm), and stage 1A3 (T1cN0M0, T1c tumor between 2 and 3 cm).
• Clinical AJCC stage IB defined as T2aN0M0, T2a tumor between 3 and 4 cm.
• Clinical AJCC stage IIA defined as T2bN0M0, T2b tumor between 4 and 5 cm.
• Lesions must be defined as central or ultra-central according to the Hilus-trial13

criteria:

• Central lesions are defined as lesions 1 cm or less from the trachea, carina, main bronchi, bronchus intermedius, or lobar bronchi.
• Ultra-central lesions are defined as lesions touching the trachea, carina, main bronchi, bronchus intermedius, or lobar bronchi. Lesions that touch the esophagus or great vessels may also be included as ultra-central.
• Tumor coverage is deemed adequate in simulation treatment planning as determined by the treating and study physicians. Specifically, the dose to 98% of the GTV must be greater than 45 Gy.
• Note: patients with inadequate tumor coverage at simulation will be considered screen-failures and treated off-protocol as per institutional standard-of-care. *In a in silico analysis of these patients, only 1/6 patients screen-failed based on this inclusion criteria.
• Patients should be able to hold their breath for 10 seconds.
• Inoperable disease or patient has refused/declined surgery.
• Deemed medically fit for SBRT by the treating physician.
• At least 18 years of age.
• Zubrod Performance Status 0-2 within 30 days prior to registration.
• Appropriate stage for protocol entry based upon the following minimum diagnostic workup.
• History/physical examination within 30 days prior to registration.
• FDG-PET/CT scan and/or CT chest (with or without contrast) for staging within 60 days prior to registration.
• Adequate bone marrow and hemostasis function determined no more than 30 days prior to

registration, defined as follows:

• Platelets = 150,000 cells/mm3
• Hemoglobin = 8 g/dl
• Able to understand and willing to sign an IRB approved written informed consent.

Exclusion Criteria:

• Lesions appearing to extend through the bronchial or great vessel walls on CT imaging.
• Prior or concurrent malignancies, unless the natural history of the prior or concurrent malignancy does not have the potential to interfere with the interpretation of the results of the study.
• Patients with a pre-existing, active diagnosis of metastatic cancer.
• Severe, active comorbidity, defined as follows:
• Unstable angina, history of myocardial infarction and/or congestive heart failure requiring hospitalization within the last 6 months;
• Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration;
• Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration;
• Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol.
• Past history of radiotherapy within the projected treatment field of any of the disease sites to be treated by CT-guided SBRT.
• Pregnant and/or breastfeeding. Patient must have a negative pregnancy test within 14 days of the start of SBRT.

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Early Stage Non-small Cell Lung Cancer
• Lung Neoplasms
• Non-small Cell Lung Cancer

Intervention

Radiation:
• Computed tomography-guided stereotactic adaptive radiotherapy
Fractions will be delivered on consecutive business days.

Device:
• ETHOS
ETHOS is a unique ring-gantry CT-guided linear accelerator notable for having an on-board cone beam CT (CBCT) imaging unit with improved definition and resolution to enable target and organ-at-risk contouring. It also has a dedicated artificial intelligence treatment planning system to allow for online adaptive radiotherapy.

Locations

Country	Name	City	State
United States	Washington University School of Medicine	Saint Louis	Missouri

Sponsors (2)

Lead Sponsor	Collaborator
Washington University School of Medicine	Varian Medical Systems

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of grade 3 or greater toxicity	-Toxicity graded per CTCAE version 5.	12 months post-completion of treatment (estimated to be 12 months and 5 days)

External Links

•   Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine