| Eligibility |
Inclusion Criteria:
1. Subject or subject's legally acceptable representative has provided informed consent
prior to initiation of any study specific activities/procedures.
2. Age =19 years of age
3. Histologically or pathologically documented, locally-advanced and unresectable or
metastatic NSCLC.
4. have documentation of KRAS p.G12C mutation confirmed by local testing through the
current protocol or have documentation of KRAS p.G12C mutation prior to enrollment.
5. Subjects will have received and progressed or experienced disease recurrence on or
after receiving at least 1 prior systemic therapy for locally advanced and
unresectable or metastatic disease.
6. Adjuvant therapy will count as a line of therapy if the subject progressed on or
within 6 months of adjuvant therapy administration.
7. In locally advanced and unresectable NSCLC, disease progression on or within 6 months
of end of prior curatively intended multimodal therapy will count as a line of
therapy. If chemoradiation is followed by planned systemic therapy without documented
progression between chemoradiation and systemic therapy, the entire treatment course
counts as one line of therapy.
8. Maintenance therapy following platinum doublet-based chemotherapy is not considered as
a separate line of therapy.
9. Subjects must have archived tumor tissue samples (formalin fixed, paraffin embedded
[FFPE] sample [FFPE of excisional, core needle, or fine needle aspirate] collected
within 5 years) or be willing to undergo pre-treatment b iopsy (excisional, core
needle, or fine needle aspirate) for tissue prior to enrollment.
10. Measurable disease per RECIST v1.1 criteria.
11. ECOG Performance Status of = 1
12. Adequate hematologic laboratory assessments, defined as the following within 28 days
prior to start of study therapy:
1. Absolute neutrophil count (ANC) = 1500 cells/µl (without granulocyte
colony-stimulating factor support within 10 days of laboratory test used to
determine eligibility)
2. Hemoglobin = 9.0 g/dL (without transfusion within 2 weeks of laboratory test used
to determine eligibility)
3. Platelet count = 100,000/µl (without transfusion within 2 weeks of laboratory
test used to determine eligibility)
13. Life expectancy of > 3 months, in the opinion of the investigator
14. Adequate liver function, defined as the following:
1. Aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) = 2.5 times
the upper limit of normal (ULN), except if alkaline phosphatase > 2.5 times the
ULN, then AST and/or ALT must be = 1.5 times the ULN
2. Serum bilirubin = 1.0 x ULN
3. International normalized ratio (INR) and activated partial thromboplastin time =
1.5 x ULN
4. Serum creatinine =1.5 x ULN OR creatinine clearance = 60 mL/min. Cockcroft- Gault
formula will be used for creatinine clearance calculation. Twenty-four hour urine
collection is not required but is allowed.
15. QTc = 470 msec in females and = 450 msec in males (based on average of screening
triplicates)
-Subject should perform 12-lead ECG 3times within 15minutes at intervals of 2-5
minutes after resting in the sitting position for 5minutes.
16. Ability to take oral medications and willing to record daily adherence to
investigational product
Exclusion Criteria:
1. Previously identified driver mutation (according to local standard of care or
guidelines) other than KRAS p.G12C for which an approved therapy is available
(including EGFR, ALK, ROS1, BRAF etc)
2. Active brain metastases. Subjects who have had brain metastases resected or have
received whole brain radiation therapy ending at least 4 weeks (or stereotactic
radiosurgery ending at least 2 weeks) prior to study day 1 are eligible if they meet
all of the following criteria:
1. residual neurological symptoms grade = 2;
2. on stable doses of dexamethasone or equivalent for at least 2 weeks, if
applicable; and
3. follow-up MRI performed within 30 days prior to enrollment shows no progression
or new lesions appearing.
3. Leptomeningeal disease.
4. Exclusion of hepatitis infection based on the following results and/or criteria:
1. Positive hepatitis B surface antigen (HepBsAg) (indicative of chronic Hepatitis B
or recent acute hepatitis B)
2. Subjects with a prior history of HBV proven to be positive for hepatitis B core
antibody
1. Surface antigen (HBsAg) is negative
2. It is suitable if the HBV deoxyribonucleic acid (DNA; viral load) is less
than the lower limit of quantitation according to the local test. Subjects
positive for HBsAg due to recent vaccination are eligible if their HBV DNA
(viral load) is below the lower limit of quantitation according to local
testing.
5. Malignancy other than NSCLC within 2 years prior to first dose of drug, with the
exception of those with a negligible risk of metastases or death and treated with
expected curative outcome (such as adequately treated carcinoma in situ of the cervix,
basal cell carcinoma, cutaneous squamous cell carcinoma, localized prostate cancer
treated with curative intent, or ductal carcinoma in situ treated surgically with
curative intent).
6. Significant gastrointestinal disorder that results in significant malabsorption,
requirement for intravenous alimentation, or inability to take oral medication.
7. Significant cardiovascular disease, myocardial infarction within 6 months prior to
study day 1, unstable arrhythmias or unstable angina.
8. Severe infections within 4 weeks prior to first dose of drug including, but not
limited to hospitalization for complications of infection, bacteremia or severe
pneumonia.
9. Subjects participating in other clinical trials are excluded.
10. Previous treatment with sotorasib or other KRAS G12C inhibitor
11. Female subjects of childbearing potential unwilling to use 1 highly effective method
of contraception during treatment and for an additional 7 days after the last dose of
sotorasib.
12. Female subjects of childbearing potential with a positive pregnancy test assessed at
Screening or day 1 by a serum pregnancy test and/or urine pregnancy test.
13. Male subjects with a female partner of childbearing potential who are unwilling to
practice sexual abstinence (refrain from heterosexual intercourse) or use
contraception during treatment and for an additional 7 days (sotorasib).
14. Subject likely to not be available to complete all protocol-required study visits or
procedures, and/or to comply with all required study procedures (eg, Clinical Outcome
Assessments) to the best of the subject and investigator's knowledge.
15. History or evidence of any other clinically significant disorder, condition or disease
(with the exception of those outlined above) that, in the opinion of the investigator
or Amgen physician, if consulted, would pose a risk to subject safety
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