Non Small Cell Lung Cancer Clinical Trial
Official title:
Effect of Copper Transporter-1 Genetic Polymorphism on Platinum Based Chemotherapy Response in Advanced Non-Small Cell Lung Cancer Patients
Study the effect of genetic polymorphism in the membrane copper transporter 1 protein [CTR1;
encoded by the solute carrier family 31 member 1 gene (SLC31A1 gene)] and its genetic
expression levels on the clinical outcome of cisplatin-based regimen used in the treatment of
Non-Small Cell Lung Cancer (NSCLC) in terms of :
- Treatment response : partial response (PR) / complete response (CR) and Progression-free
survival (PFS)
- Treatment resistance : stationary disease (SD) or progressed disease
- Frequency and severity of regimen related toxicity
The cisplatin-based regimen is an effective treatment for advanced NSCLC, showing significant
beneficial outcomes such as prolong survival, improve clinical symptoms, and improve quality
of life (QOL) . Although platinum-based therapy shows several benefits, but the five-year
survival rate still less than 20%.
Pt resistance is an inevitable occurrence with rare exception. Aside from germ cell tumors,
metastatic solid tumors are generally thought to be incurable with cytotoxic chemotherapy due
to the development of resistance and subsequent disease progression.
Despite the multifactorial nature of Cisplatin resistance, intracellular accumulation of Pt
appears to be a major source of drug resistance . Reduced intracellular drug accumulation is
one of the most consistently identified features of cisplatin-resistant cells.
Many evidences indicated that alteration of copper transporter protein 1 (CTR1) which is the
major plasma membrane transporter responsible for platinum uptake, was associated with
platinum sensitivity and toxicity.
Genetic polymorphisms of CTR1 also have effects to platinum treatment response. Therefore,
CTR1 might be a potential prognostic factor for survival in cancer patients underwent
chemotherapy and a treatment target for overcoming platinum resistance.
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