Non Small Cell Lung Cancer Clinical Trial
Official title:
WHENII - Early Response Evaluation With 18F-2-fluoro-2-deoxy-D-glucose Fluorodeoxyglucose(FDG)- Positrons Emissions Tomography(PET)/CT and Liquid Biopsy in Patients With NSCLC (Non Small Cell Lung Cancer)
Response evaluation with FDG-PET and free circulating DNA in patients with inoperable lung cancer of non small cell type during first treatment with chemotherapy or immunotherapy.
Interventional study of patients with inoperable lung cancer of non small cell type
undergoing 1st treatment of either chemotherapy or immunotherapy. Patients are evaluated with
FDG-PET/ct and blood analyses og circulating tumor DNA and cancer markers to determine early
response.
PET-CT are preceded before and after treatment is given;
- day 0 before treatment,
- day 2 after treatment and
- day 21 just before second treatment. At every FDG-PET/ct scan blood are examined for
circulating tumor DNA (ctDNA) and potentially cancer markers by White genome sequencing.
In total 3 PET-CT scans and 4 blood samples are performed. The result are compared with
the standard CT scan after 2-3 cycles of treatment. Blood analyses are repeated after
2-3 cycles to observe any changes.
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