Non Small Cell Lung Cancer Clinical Trial
Official title:
Phase I Study of PET/CT-directed Hyperfractionated Radiation Dose Escalation With Concurrent Weekly Carboplatin and Paclitaxel in Stage III Non-small Cell Lung Cancer
The goal of this study is to find the maximum tolerable dose of radiation that can be delivered combined with chemotherapy (carboplatin & paclitaxel) in patients with stage III non-small cell lung cancer (NSCLC).
Concurrent chemoradiotherapy is the standard of care for unresectable stage III NSCLC based
on the results of phase III randomised trials. The current standard radiation therapy dose
has remained 60- Gy at -2 Gy/fraction for nearly four decades (60Gy), with local disease
control rates of approximately 50% and a median overall survival of only 18 months.These
results are suboptimal and more effective treatment regimens are needed.
We hypothesize that hyperfractionated radiation dose escalation to residual tumor volumes
after standard chemoradiotherapy as defined by positron emission tomography (PET) /computed
tomography (CT) would improve local control and overall survival while reducing the acute and
late normal tissue toxicity.
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