Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase II Study of Accelerated Hypofractionated Three-dimensional Conformal Radiation Therapy Concurrent With Chemotherapy in Unresectable Stage III Non-small Cell Lung Cancer
The purpose of this study is to evaluate the safety of accelerated hypofractionated three-dimensional conformal radiation therapy (3 Gy/fraction) concurrent with chemotherapy for patients with unresectable stage III non-small cell lung cancer.
Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer
(NSCLC) can increase local control rates and improve overall survival. Compared with
conventional fractionated radiotherapy, accelerated hypofractionated radiotherapy can yield
higher BED, shorten the total treatment time, and theoretically obtain better efficacy.
However, currently, there is no optimal hypofractionated radiotherapy regimen. Based on phase
I trial results, we performed this phase II trial to further evaluate the safety and
preliminary efficacy of accelerated hypofractionated three-dimensional conformal radiation
therapy(3-DCRT) combined with concurrent chemotherapy for patients with unresectable stage
III NSCLC.
Patients with previously untreated unresectable stage III NSCLC received 3-DCRT with a total
dose of 69 Gy, delivered at 3 Gy per fraction, once daily, five fractions per week, completed
within 4.6 weeks. At the same time, platinum doublet chemotherapy was applied.
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