Non Small Cell Lung Cancer Clinical Trial
Official title:
Human EGFR(Epidermal Growth Factor Receptor) Mutations Quantitative Detection Kit (Real-time Fluorescent PCR Method)
In this clinical trial, investigators select FFPE and plasma samples of non-small cell lung
cancer which are used for quantitative detection of four kinds of EGFR(Epidermal Growth
Factor Receptor) mutations. By the following two aspects, investigators evaluate the
clinical performance of the EGFR quantitative kits.
1. methodology validation: To certify the equivalence between the EGFR quantitative kit
and the common used detection methods.
2. analysis of the relationship between the type and proportion of EGFR sensitive mutation
and EGFR-TKI benefit.
According to the types of samples and the purpose of the study, the research consists of two groups: plasma and tissue matching group and predicting clinical efficacy group. The samples of the plasma and tissue matching group are the same period plasma and matched FFPE(formalin-fixed paraffin-embedded tissue)samples which will be collected before the first time patients accept any anti-tumor treatment. The samples of predicting clinical efficacy group are FFPE samples which will be collected before the patients receive EGFR-TKI treatment. In addition, the subjects have the complete prognostic follow-up data. ;
Observational Model: Cohort, Time Perspective: Retrospective
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