Non-small Cell Lung Cancer Clinical Trial
Official title:
Micro RNA Genetic Signature in Non-small Cell Lung Cancer Egyptian Patients
Verified date | October 2016 |
Source | Tanta University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Egypt: Ministry of Higher Education |
Study type | Observational |
This study will be carried out on 40 subjects at Chest department Tanta university hospital
The subjects will be classified into three groups:
- Group I: will include ten non smoker volunteers (control group I).
- GroupII: will include ten smoker volunteers (control groupII).
- Group III: will include twenty NSCLC patients confirmed by pathological examination of
bronchoalveolar examination (BAL), brush and/or biopsy.
Status | Completed |
Enrollment | 40 |
Est. completion date | August 2016 |
Est. primary completion date | January 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Inclusion criteria for patients: Non small cell lung cancer patients recently diagnosed who did not receive chemotherapy, surgery or radiation therapy. Exclusion Criteria: - Exclusion criteria for patients: - Diagnosis of asthma or COPD. - Broncheiactasis. - upper/lower respiratory tract infection in the preceding 4 weeks. - Active pulmonary tuberculosis. - Associated cancer beside lung cancer. - Patients who received chemotherapy, surgery or radiation therapy previous to the sample collection. Exclusion criteria for control subjects: - Diagnosis of asthma or COPD. - Broncheiactasis. - Upper/lower respiratory tract infection in the preceding 4 weeks. - Active pulmonary tuberculosis - Smoking in group I. |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Egypt | Chest Department, Faculty of Medicine, Tanta University | Tanta | Gharbia |
Lead Sponsor | Collaborator |
---|---|
Adel Salah Bediwy |
Egypt,
Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F, Scheffler M, Huwer H, Lenhof HP, Meese E. miRNAs in lung cancer - studying complex fingerprints in patient's blood cells by microarray experiments. BMC Cancer. 2009 Oct 6;9:353. doi: 10.1186/1471-2407-9-353. — View Citation
Leidinger P, Keller A, Meese E. MicroRNAs - Important Molecules in Lung Cancer Research. Front Genet. 2012 Jan 23;2:104. doi: 10.3389/fgene.2011.00104. — View Citation
Tang D, Shen Y, Wang M, Yang R, Wang Z, Sui A, Jiao W, Wang Y. Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer. Eur J Cancer Prev. 2013 Nov;22(6):540-8. doi: 10.1097/CEJ.0b013e32835f3be9. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Detect micro RNA genetic signature pattern in non-small cell lung cancer Egyptian patients assessed using Microarray | one year | Yes |
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