Non-Small Cell Lung Cancer Clinical Trial
Official title:
A Phase I Study of Tetrathiomolybdate (TM) in Combination With Carboplatin and Pemetrexed in Chemo-Naive Metastatic or Recurrent Non-Squamous Non-Small Cell Lung Cancer
The main objective of this study is to determine recommended phase II dose and safety of tetrathiomolybdate (TM) in combination with carboplatin and pemetrexed in chemo-naive metastatic or recurrent non-squamous non-small cell lung cancer.
Platinum resistance is a major limitation in the treatment of advanced non-small cell lung
cancer. Previous studies suggest that reduced tumor platinum levels may significantly
contribute to platinum resistance and thus poor outcome following platinum-based chemotherapy
in lung cancer.
Tetrathiomolybdate (TM) is a fast-acting copper chelator that has been under significant
investigation as an anti-cancer strategy due to its anti-angiogenic property. Furthermore,
more recent preclinical evidence suggests that combining TM with platinum drugs resulted in
higher intratumoral platinum concentration and greater tumor response. The oncologists at the
University of Rochester are studying addition of TM to commonly used 1st line platinum-based
doublet, carboplatin/pemetrexed, in patients with non-squamous non-small cell lung cancer.
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